Double-pronged Antimicrobial Agents based on a Donor-pi-Acceptor Type Aggregation-Induced Emission Luminogen

Wu, Yifan1,2; Li, Jiangao1,2; Shen, Zipeng1; Wang, Deliang1; Dong, Ruihua6; Zhang, Jiangjiang7; Pan, Yinzhen1; Li, Ying1,3,4,5; Wang, Dong1; Tang, Ben Zhong6

2022-10-01

10.1002/anie.202212386

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   影响因子和分区

1433-7851

1521-3773

Novel antibacterial agents are urgently needed to control the infections induced by multidrug-resistant (MDR) bacteria. Herein, we rationally designed and facilely synthesized a new D-pi-A type luminogen with strong red/near-infrared fluorescence emission, great aggregation-induced emission (AIE) features, and excellent reactive oxygen species (ROS) production. The newly developed molecule TTTh killed the methicillin-resistant Staphylococcus aureus (MRSA) by triggering the ROS accumulation in bacteria and interrupting the membrane integrity. Moreover, TTTh specifically targeted the lysosomes and potentiated their maturation to accelerate the clearance of intracellular bacteria. Additionally, reduced bacterial burden and improved healing were observed in TTTh-treated wounds with negligible side effects. Our study expands the biological design and application of AIE luminogens (AIEgens), and provides new insights into discovering novel antibacterial targets and agents.

Aggregation-Induced Emission Host-Directed Antibacterial Therapies Lysosome Macrophage Multidrug-Resistant Bacteria

SCI

英语

NI论文

其他

National Natural Science Foundation of China["22005195","52122317","22175120"] ; Science and Technology Foundation of Shenzhen City["JCYJ20200109110608167","RCYX20200714114525101"] ; Shenzhen Key Laboratory of Functional Aggregate Materials[ZDSYS20211021111400001]

Chemistry

Chemistry, Multidisciplinary

WOS:000870421900001

WILEY-V C H VERLAG GMBH

CHEMISTRY

Web of Science

1.Shenzhen Univ, Coll Mat Sci & Engn, Ctr AIE Res,Shenzhen Key Lab Polymer Sci & Techno, Guangdong Res Ctr Interfacial Engn Funct Mat, Shenzhen 518060, Guangdong, Peoples R China
2.Shenzhen Univ, Coll Phys & Optoelect Engn, Key Lab Optoelect Devices & Syst, Minist Educ & Guangdong Prov, Shenzhen 518060, Guangdong, Peoples R China
3.Guangzhou Med Univ, Innovat Res Ctr AIE Pharmaceut Biol, Guangzhou Municipal & Guangdong Prov Key Lab Mol, NMPA, Guangzhou 511436, Peoples R China
4.Guangzhou Med Univ, State Key Lab Resp Dis, Sch Pharmaceut Sci, Guangzhou 511436, Peoples R China
5.Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Peoples R China
6.Chinese Univ Hong Kong, Sch Sci & Engn, Shenzhen Inst Aggregate Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China
7.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

Wu, Yifan,Li, Jiangao,Shen, Zipeng,et al. Double-pronged Antimicrobial Agents based on a Donor-pi-Acceptor Type Aggregation-Induced Emission Luminogen[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2022.

Wu, Yifan.,Li, Jiangao.,Shen, Zipeng.,Wang, Deliang.,Dong, Ruihua.,...&Tang, Ben Zhong.(2022).Double-pronged Antimicrobial Agents based on a Donor-pi-Acceptor Type Aggregation-Induced Emission Luminogen.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.

Wu, Yifan,et al."Double-pronged Antimicrobial Agents based on a Donor-pi-Acceptor Type Aggregation-Induced Emission Luminogen".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022).