Dual targeting nanoparticles for epilepsy therapy

Hou，Qinghong1,2,3; Wang，Lulu4; Xiao，Feng1; Wang，Le1; Liu，Xiaoyan1; Zhu，Lina3; Lu，Yi4; Zheng，Wenfu2; Jiang，Xingyu1

2022

10.1039/d2sc03298h

Chemical Science   影响因子和分区

2041-6520

2041-6539

For epilepsy therapy, one-third of the patients worldwide are resistant to antiepileptic drugs mainly due to the existence of the blood-brain barrier (BBB) that prevents the drugs from reaching the epileptic lesions. Here, we design a double targeting nanoparticle carrying lamotrigine (LTG) to cross the BBB and further concentrate at the neurons. We prepare the nanoparticles on a microfluidic chip by encapsulating LTG in poly(lactic-co-glycolic acid) (PLGA) to form a core (PL) and capping the core with a shell of lipids conjugated with the D-T7 peptide (targeting the BBB) and Tet1 peptide (targeting the neuron) to form D-T7/Tet1-lipids@PL nanoparticles (NPs). In vitro and in vivo experiments show that D-T7/Tet1-lipids@PL NPs have excellent neuron targeting, antiepileptic, and protecting effects. Our approach provides a new strategy for improving the therapeutic efficacy of existing antiepileptic drugs.

SCI ; EI

英语

NI论文

第一 ; 通讯

National Key R&D Program of China["2021YFF1200800","2020YFA0908900","2018YFA0902600","2021YFF1200100"] ; National Natural Science Foundation of China["32071390","81730051"] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009] ; Shenzhen Science and Technology Program[KQTD20190929172743294] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH039] ; Shenzhen Bay Laboratory[SZBL2019062801004] ; Guangdong Innovative and Entrepreneurial Research Team Program[2019ZT08Y191]

Chemistry

Chemistry, Multidisciplinary

WOS:000874887500001

ROYAL SOC CHEMISTRY

20224613121989

Neurons ; Patient treatment ; Peptides

Medicine and Pharmacology:461.6 ; Biology:461.9 ; Nanotechnology:761 ; Solid State Physics:933

2-s2.0-85141868296

Scopus

1.Shenzhen Key Laboratory of Smart Healthcare Engineering,Guangdong Provincial Key Laboratory of Advanced Biomaterials,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology,Beijing,100190,China
3.Department of Chemistry,School of Science,Tianjin University,Tianjin,300350,China
4.CAS Key Laboratory of Brain Connectome and Manipulation,the Brain Cognition and Brain Disease Institute,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen,518055,China

Hou，Qinghong,Wang，Lulu,Xiao，Feng,et al. Dual targeting nanoparticles for epilepsy therapy[J]. Chemical Science,2022.

Hou，Qinghong.,Wang，Lulu.,Xiao，Feng.,Wang，Le.,Liu，Xiaoyan.,...&Jiang，Xingyu.(2022).Dual targeting nanoparticles for epilepsy therapy.Chemical Science.

Hou，Qinghong,et al."Dual targeting nanoparticles for epilepsy therapy".Chemical Science (2022).