Research progress on pharmacological effect of evodiamine ? 茱 ? 碱的 ? ? 学研究进

Liang，Jing Rong1,2; Mai，Feng Yi3; Li，Chen Guang1,2; Liao，Xiang2; Zhang，Zhi Guo1

2022

10.12360/CPB202201066

中国药理学通报   影响因子和分区

1001-1978

Evodiamine(EVO)is an indoloquinazoline alkaloid isolated from the fruits of Euodia rutaecarpa,which has long been used in traditional Chinese medicine to treat various diseases.Modern medical research shows that evodiamine has various pharmacological activities and extremely high medicinal value such as anti-inflammation,anti-tumor,losing weight,treating Alzheimer's,and antibacterium.Evodiamine can interact with a variety of proteins.For example,the interaction between evodiamine and TRPV1 induces its activation to exert anti-inflammatory and losing weight; the interaction with DNA topoisomerase I inhibits its function and thus inhibit bacterial proliferation; the interaction with tubulin promotes NLRP3 inflammasome activation,and exerts anti-tumor and anti-inflammatory functions.In recent years,with the in-depth study of evodiamine,pharmacological research and mechanism of evodiamine has significant improvement.Recent progress of pharmacological effect of evodiamine is highlighted in this review.

Euodiae Fructus evodiamine pharmacological activities protein targets research progress safe medication

中文

其他

2-s2.0-85141832252

Scopus

1.Shenzhen University Health Science Center,School of Biomedical Engineering,Shenzhen,518060,China
2.Huazhong University of Science and Technology Union Shenzhen Hospital,Pain Management,Shenzhen,518052,China
3.Southern University of Science and Technology,Dept of Medicine,Shenzhen,518055,China

Liang，Jing Rong,Mai，Feng Yi,Li，Chen Guang,等. Research progress on pharmacological effect of evodiamine ? 茱 ? 碱的 ? ? 学研究进[J]. 中国药理学通报,2022,38(10):1457-1461.

Liang，Jing Rong,Mai，Feng Yi,Li，Chen Guang,Liao，Xiang,&Zhang，Zhi Guo.(2022).Research progress on pharmacological effect of evodiamine ? 茱 ? 碱的 ? ? 学研究进.中国药理学通报,38(10),1457-1461.

Liang，Jing Rong,et al."Research progress on pharmacological effect of evodiamine ? 茱 ? 碱的 ? ? 学研究进".中国药理学通报 38.10(2022):1457-1461.