南方科技大学知识苑(SUSTech KC): In Vivo Imaging of Exosomes Labeled with NIR-II Polymer Dots in Liver-Injured Mice

题名	In Vivo Imaging of Exosomes Labeled with NIR-II Polymer Dots in Liver-Injured Mice
作者	Ma，Ning 1; Liu，Ye2 ; Chen，Dandan2 ; Wu，Changfeng2 ; Meng，Zihui 1
通讯作者	Meng，Zihui
发表日期	2022
DOI	10.1021/acs.biomac.2c01005
发表期刊	BIOMACROMOLECULES 影响因子和分区
ISSN	1525-7797
EISSN	1526-4602
摘要	Mesenchymal stem cell-derived exosomes (MSC-Exos) are emerging as a promising platform for treating various intractable diseases and organ injuries. Monitoring their migration, homing, and therapeutic capability in vivo is essential to develop exosome-based theranostics. Here, we designed fluorescent semiconductor polymer dots (Pdots) in the second near-infrared window (NIR-II) for bright labeling and tracking of MSC-Exos. Glucose-coated Pdots (Pdots-Glu) were able to label MSC-Exos without changing their biological properties. The NIR-II fluorescent Pdots allow for high labeling brightness and long-term in vivo tracking of MSC-Exos. We investigated the biodistributions and therapeutic functions of these labeled MSC-Exos in liver-resected mice. In vivo and ex vivo imaging demonstrated that the Pdot-labeled MSC-Exos injected via the tail vein mainly accumulated in the residual liver tissue. In terms of the therapeutic effect, MSC-Exos may accelerate postoperative liver function recovery by inhibiting inflammatory responses, promoting cell proliferation, and resisting apoptosis. Our results indicated that MSC-Exos therapeutic systems hold promising applications in liver regenerative medicine.
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	[20180201055YY]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
WOS记录号	WOS:000878942500001
出版者	AMER CHEMICAL SOC
ESI学科分类	BIOLOGY & BIOCHEMISTRY
Scopus记录号	2-s2.0-85141644254
来源库	Scopus
引用统计	被引频次[WOS]：6
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/411881
专题	工学院_生物医学工程系
作者单位	1.Department of Hepatobiliary-Pancreatic Surgery,China-Japan Union Hospital,Jilin University,Changchun,Jilin,130000,China 2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
推荐引用方式 GB/T 7714	Ma，Ning,Liu，Ye,Chen，Dandan,et al. In Vivo Imaging of Exosomes Labeled with NIR-II Polymer Dots in Liver-Injured Mice[J]. BIOMACROMOLECULES,2022.
APA	Ma，Ning,Liu，Ye,Chen，Dandan,Wu，Changfeng,&Meng，Zihui.(2022).In Vivo Imaging of Exosomes Labeled with NIR-II Polymer Dots in Liver-Injured Mice.BIOMACROMOLECULES.
MLA	Ma，Ning,et al."In Vivo Imaging of Exosomes Labeled with NIR-II Polymer Dots in Liver-Injured Mice".BIOMACROMOLECULES (2022).