南方科技大学知识苑(SUSTech KC): Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways

题名	Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways
作者	Yang，Zhiwen; Yu，Zongyan; Xiao，Bo
通讯作者	Yu，Zongyan; Xiao，Bo
发表日期	2022
DOI	10.1007/s12264-022-00967-x
发表期刊	Neuroscience Bulletin 影响因子和分区
ISSN	1673-7067
EISSN	1995-8218
卷号	39 期号:3
摘要	Myelin-forming oligodendrocytes in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS) are essential for structural and functional homeostasis of nervous tissue. Albeit with certain similarities, the regulation of CNS and PNS myelination is executed differently. Recent advances highlight the coordinated regulation of oligodendrocyte myelination by amino-acid sensing and growth factor signaling pathways. In this review, we discuss novel insights into the understanding of differential regulation of oligodendrocyte and Schwann cell biology in CNS and PNS myelination, with particular focus on the roles of growth factor-stimulated RHEB-mTORC1 and GATOR2-mediated amino-acid sensing/signaling pathways. We also discuss recent progress on the metabolic regulation of oligodendrocytes and Schwann cells and the impact of their dysfunction on neuronal function and disease.
关键词	GATOR2 lactate MIOS mitochondria mTORC1 myelination Oligodendrocyte RHEB Schwann cell
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Shenzhen Innovation Committee of Science and Technology["ZDSYS20200811144002008","2019193984"] ; National Natural Science Foundation of China["31970773","31530042"] ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions[2021SHIBS0002]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000880502700001
出版者	SPRINGER
Scopus记录号	2-s2.0-85141637082
来源库	Scopus
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/411883
专题	生命科学学院_生物系生命科学学院
作者单位	Shenzhen Key Laboratory of Gene Regulation and Systems Biology,Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518000,China
第一作者单位	生物系; 生命科学学院
通讯作者单位	生物系; 生命科学学院
第一作者的第一单位	生物系; 生命科学学院
推荐引用方式 GB/T 7714	Yang，Zhiwen,Yu，Zongyan,Xiao，Bo. Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways[J]. Neuroscience Bulletin,2022,39(3).
APA	Yang，Zhiwen,Yu，Zongyan,&Xiao，Bo.(2022).Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways.Neuroscience Bulletin,39(3).
MLA	Yang，Zhiwen,et al."Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways".Neuroscience Bulletin 39.3(2022).