Strontium-modified porous polyetheretherketone with the triple function of osteogenesis, angiogenesis, and anti-inflammatory for bone grafting

Hu, Liqiu1; Ge, Yongmei1; Cao, Zhe1; Tian, Ye2; Sun, QiLi1; Li, Zhen3; Ma, Jing4; Wu, Yutong1; Wang, Ning5; Tang, Bin1

2022-12-01

10.1016/j.bioadv.2022.213160

BIOMATERIALS ADVANCES   影响因子和分区

2772-9508

Polyetheretherketone (PEEK) is a potential bone repair material because of its stable chemical and good me-chanical properties. However, the biological inertness of PEEK limits its clinical application. Sr2+ has multi biological functions, including promoting bone formation and blood vessel regeneration and inhibiting inflam-mation. In this paper, PEEK was modified with Sr2+ with the purpose to construct PEEK bone graft material with triple functions of osteogenesis, angiogenesis, and anti-inflammatory. The results showed that Sr-modified PEEK could stably release Sr2+ for a long time in the PBS solution, and indeed could promote the proliferation and differentiation of osteoblasts, promote angiogenesis, and inhibit inflammation. Therefore, it is believed that this multifunctional PEEK with Sr2+ should show great promise for clinical applications in bone repair.

Polyetheretherketone Osteogenesis Angiogenesis Anti-inflammatory

SCI

英语

第一 ; 通讯

[2019YFA0906004] ; [11872200] ; [JSGG20200225151916021] ; [JSSCBS20210911]

Materials Science

Materials Science, Biomaterials

WOS:000883917000004

ELSEVIER

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China
2.Univ Hong Kong, Dept Mech Engn, Pokfulam, Hong Kong, Peoples R China
3.Jiangsu Univ Technol, Sch Chem & Environm Engn, Changzhou 213001, Jiangsu, Peoples R China
4.Southern Univ Sci & Technol Hosp, Smart Biomat Design Lab, Shenzhen 518055, Guangdong, Peoples R China
5.Shenzhen Technol Univ, Coll New Mat & New Energies, Shenzhen 518055, Guangdong, Peoples R China

Hu, Liqiu,Ge, Yongmei,Cao, Zhe,et al. Strontium-modified porous polyetheretherketone with the triple function of osteogenesis, angiogenesis, and anti-inflammatory for bone grafting[J]. BIOMATERIALS ADVANCES,2022,143.

Hu, Liqiu.,Ge, Yongmei.,Cao, Zhe.,Tian, Ye.,Sun, QiLi.,...&Tang, Bin.(2022).Strontium-modified porous polyetheretherketone with the triple function of osteogenesis, angiogenesis, and anti-inflammatory for bone grafting.BIOMATERIALS ADVANCES,143.

Hu, Liqiu,et al."Strontium-modified porous polyetheretherketone with the triple function of osteogenesis, angiogenesis, and anti-inflammatory for bone grafting".BIOMATERIALS ADVANCES 143(2022).