南方科技大学知识苑(SUSTech KC): Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study

题名	Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study
作者	Ju，Chunrong 1; Wang，Xiaohua 1; Xu，Xin 1; Xie，Shaobo 1; Cao，Qingdong 2; Lin，Wanli 3; Zhang，Jianheng 1; Xu，Yu 1; Lian，Qiaoyan 1; Huang，Danxia 1; Chen，Rongchang 4; He，Jianxing 1
通讯作者	Chen，Rongchang; He，Jianxing
发表日期	2022-12-01
DOI	10.1186/s12879-022-07853-x
发表期刊	BMC Infectious Diseases 影响因子和分区
EISSN	1471-2334
卷号	22 期号:1
摘要	Background: Cytomegalovirus (CMV) infection is a leading cause of morbidity and mortality after transplantation. This study aimed to investigate CMV seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients. Methods: The clinical data of the patients who underwent lung and/or heart transplantation between January 2015 and October 2020 were retrospectively collected from four transplantation centers in China. Results: A total of 308 patients were analyzed. The CMV serostatus was donor positive (D) recipient negative (R) in 19 (6.17%) patients, D/R in 233 (75.65%), D/R in 36 (11.69%), and D/R in 20 (6.50%). CMV DNAemia was detected in 52.3% of the patients and tissue-invasive CMV disease was diagnosed in 16.2% of the patients. Only 31.8% of the patients adhered to the postdischarge valganciclovir therapy. The D/R serostatus (odds ratio [OR]: 18.32; 95% confidence interval [CI]:1.80-188.68), no valganciclovir prophylaxis (OR: 2.64; 95% CI: 1.05–6.64), and higher doses of rabbit anti-human thymocyte globulin (> 2 mg/kg) (OR: 4.25; 95% CI: 1.92–9.42) were risk factors of CMV disease. Conclusion: CMV seroprevalence was high in Chinese thoracic organ transplant donors and recipients. The low adherence rate to the postdischarge CMV prophylaxis therapy in Chinese patients is still an unresolved issue.
关键词	Cytomegalovirus Pneumonia Seroprevalence Thoracic organ transplant Valganciclovir
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	Natural Science Foundation of Guangdong Province[2018A030313107];State Key Laboratory of Respiratory Disease[SKLRD-QN-201710];
WOS研究方向	Infectious Diseases
WOS类目	Infectious Diseases
WOS记录号	WOS:000886964000007
出版者	BMC
ESI学科分类	IMMUNOLOGY
Scopus记录号	2-s2.0-85142263797
来源库	Scopus
引用统计	被引频次[WOS]：2
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/412550
专题	南方科技大学南方科技大学第二附属医院
作者单位	1.Guangzhou Institute of Respiratory Health,First Affiliated Hospital of Guangzhou Medical University,Guangzhou,Yanjiang Road,China 2.Department of Thoracic Surgery and Lung Transplantation,Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,China 3.Department of Thoracic Surgery,The People’s Hospital of Gaozhou,Gaozhou,China 4.Shenzhen People’s Hospital Institute of Respiratory Diseases,Southern University of Science and Technology,University of Jinan Second Clinical Medical College,Shenzhen,East of Shennan Road, Luohu District,China
通讯作者单位	南方科技大学
推荐引用方式 GB/T 7714	Ju，Chunrong,Wang，Xiaohua,Xu，Xin,et al. Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study[J]. BMC Infectious Diseases,2022,22(1).
APA	Ju，Chunrong.,Wang，Xiaohua.,Xu，Xin.,Xie，Shaobo.,Cao，Qingdong.,...&He，Jianxing.(2022).Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study.BMC Infectious Diseases,22(1).
MLA	Ju，Chunrong,et al."Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study".BMC Infectious Diseases 22.1(2022).