南方科技大学知识苑(SUSTech KC): A microbial transporter of the dietary antioxidant ergothioneine

题名	A microbial transporter of the dietary antioxidant ergothioneine
作者	Dumitrescu，Daniel G.1,2,3; Gordon，Elizabeth M.1,3; Kovalyova，Yekaterina 1,2,3; Seminara，Anna B.1,3,4; Duncan-Lowey，Brianna 5,6; Forster，Emily R.7,8; Zhou，Wen9 ; Booth，Carmen J.10; Shen，Aimee 7; Kranzusch，Philip J.5,6,11; Hatzios，Stavroula K.1,2,3; Dumitrescu，Daniel G.12,13,14; Gordon，Elizabeth M.12,14; Kovalyova，Yekaterina 12,13,14; Seminara，Anna B.12,14,15; Duncan-Lowey，Brianna 16,17; Forster，Emily R.18,19; Zhou，Wen20 ; Booth，Carmen J.21; Shen，Aimee 18; Kranzusch，Philip J.16,17,22; Hatzios，Stavroula K.12,13,14
通讯作者	Hatzios，Stavroula K.; Hatzios，Stavroula K.
发表日期	2022-11-23
DOI	10.1016/j.cell.2022.10.008
发表期刊	CELL 影响因子和分区
ISSN	0092-8674
EISSN	1097-4172
卷号	185 期号:24页码:4526-4540.e18
摘要	Low-molecular-weight (LMW) thiols are small-molecule antioxidants required for the maintenance of intracellular redox homeostasis. However, many host-associated microbes, including the gastric pathogen Helicobacter pylori, unexpectedly lack LMW-thiol biosynthetic pathways. Using reactivity-guided metabolomics, we identified the unusual LMW thiol ergothioneine (EGT) in H. pylori. Dietary EGT accumulates to millimolar levels in human tissues and has been broadly implicated in mitigating disease risk. Although certain microorganisms synthesize EGT, we discovered that H. pylori acquires this LMW thiol from the host environment using a highly selective ATP-binding cassette transporter—EgtUV. EgtUV confers a competitive colonization advantage in vivo and is widely conserved in gastrointestinal microbes. Furthermore, we found that human fecal bacteria metabolize EGT, which may contribute to production of the disease-associated metabolite trimethylamine N-oxide. Collectively, our findings illustrate a previously unappreciated mechanism of microbial redox regulation in the gut and suggest that inter-kingdom competition for dietary EGT may broadly impact human health.
关键词	ABC Transporter Ergothioneine Helicobacter Pylori Host-microbe Low-molecular-weight Thiol Metabolism Microbiome Oxidative Stress Redox Regulation
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
重要成果	NI论文
学校署名	其他
资助项目	National Institute of Allergy and Infectious Diseases[R01 AI22232] ; National Institutes of Health[T32 GM067543]
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:000901783200008
出版者	CELL PRESS
ESI学科分类	MOLECULAR BIOLOGY & GENETICS
Scopus记录号	2-s2.0-85142178546
来源库	Scopus
引用统计	被引频次[WOS]：36
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/412557
专题	生命科学学院_基础免疫与微生物学系生命科学学院
作者单位	1.Department of Molecular,Cellular,and Developmental Biology,Yale University,New Haven,06520,United States 2.Department of Chemistry,Yale University,New Haven,06520,United States 3.Microbial Sciences Institute,Yale University,West Haven,06516,United States 4.Department of Microbial Pathogenesis,Yale University School of Medicine,New Haven,06520,United States 5.Department of Microbiology,Harvard Medical School,Boston,02115,United States 6.Department of Cancer Immunology and Virology,Dana-Farber Cancer Institute,Boston,02115,United States 7.Department of Molecular Biology and Microbiology,Tufts University School of Medicine,Boston,02111,United States 8.Graduate Program in Molecular Microbiology,Graduate School of Biomedical Sciences,Tufts University,Boston,02111,United States 9.Department of Immunology and Microbiology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China 10.Department of Comparative Medicine,Yale University School of Medicine,New Haven,06520,United States 11.Parker Institute for Cancer Immunotherapy at Dana-Farber Cancer Institute,Boston,02115,United States 12.Department of Molecular,Cellular,and Developmental Biology,Yale University,New Haven,06520,United States 13.Department of Chemistry,Yale University,New Haven,06520,United States 14.Microbial Sciences Institute,Yale University,West Haven,06516,United States 15.Department of Microbial Pathogenesis,Yale University School of Medicine,New Haven,06520,United States 16.Department of Microbiology,Harvard Medical School,Boston,02115,United States 17.Department of Cancer Immunology and Virology,Dana-Farber Cancer Institute,Boston,02115,United States 18.Department of Molecular Biology and Microbiology,Tufts University School of Medicine,Boston,02111,United States 19.Graduate Program in Molecular Microbiology,Graduate School of Biomedical Sciences,Tufts University,Boston,02111,United States 20.Department of Immunology and Microbiology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China 21.Department of Comparative Medicine,Yale University School of Medicine,New Haven,06520,United States 22.Parker Institute for Cancer Immunotherapy at Dana-Farber Cancer Institute,Boston,02115,United States
推荐引用方式 GB/T 7714	Dumitrescu，Daniel G.,Gordon，Elizabeth M.,Kovalyova，Yekaterina,et al. A microbial transporter of the dietary antioxidant ergothioneine[J]. CELL,2022,185(24):4526-4540.e18.
APA	Dumitrescu，Daniel G..,Gordon，Elizabeth M..,Kovalyova，Yekaterina.,Seminara，Anna B..,Duncan-Lowey，Brianna.,...&Hatzios，Stavroula K..(2022).A microbial transporter of the dietary antioxidant ergothioneine.CELL,185(24),4526-4540.e18.
MLA	Dumitrescu，Daniel G.,et al."A microbial transporter of the dietary antioxidant ergothioneine".CELL 185.24(2022):4526-4540.e18.