Duration of Diabetes, Glycemic Control, and Risk of Heart Failure Among Adults With Diabetes: A Cohort Study

Yang, Huan-Huan1; Li, Fu-Rong2,3; Chen, Ze-Kun1; Zhou, Meng-Ge1; Xie, Li-Feng1,4; Jin, Yuan-Yuan1,5; Li, Zhi-Hui1; Chen, Guo-Chong6

2022-11-01

10.1210/clinem/dgac642

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   影响因子和分区

0021-972X

1945-7197

Context The influences of diabetes duration and glycemic control and their potential interplays on the risk of heart failure (HF) remain unclear. Objective This work aimed to investigate the association of diabetes duration and glycemic control with the risk of HF. Methods A total of 23 754 individuals with diabetes but without HF during the baseline recruitment of UK Biobank were included in this study. Duration of diabetes was self-reported, and the status of glycemic control was reflected by glycated hemoglobin A(1c) (HbA(1c)) levels. Their associations with incident HF were assessed using multivariate Cox models adjusting for traditional risk factors. Results Duration of diabetes and HbA(1c) levels both were positively associated with the risk of HF. The hazard ratios (HRs) (95% CI) for diabetes durations of 5 to less than 10, 10 to less than 15, and 15 years or more were 1.09 (0.97-1.23), 1.13 (0.97-1.30), and 1.32 (1.15-1.53), respectively (vs < 5 years); and the HRs for HbA(1c) of 53.0 to less than 58.5 mmol/mol (7.0% to < 7.5%), 58.5 to less than 63.9 mmol/mol (7.5% to < 8.0%), and 63.9 mmol/mol or greater (8.0%) were 1.15 (1.02-1.31), 1.07 (0.91-1.26), and 1.46 (1.30-1.65), respectively (vs < 53.0 mmol/mol [7.0%]). Individuals with the longest disease duration (>= 15 years) and poorer glycemic control (HbA(1c) >= 63.9 mmol/mol [8.0%]) had a particularly higher risk of HF (P for interaction = .026). Conclusion The risk of HF among individuals with diabetes increases with a longer duration of diabetes and increasing HbA(1c) levels. This finding may contribute to the individualized prevention of HF in patients with diabetes if being considered in clinical practices and policy-making.

diabetes duration glycemic control glycated hemoglobin heart failure

SCI

英语

通讯

[55794]

Endocrinology & Metabolism

Endocrinology & Metabolism

WOS:000886692700001

ENDOCRINE SOC

CLINICAL MEDICINE

Web of Science

1.Tsinghua Univ, Vanke Sch Publ Hlth, 30 Shuangqing St, Beijing 100084, Peoples R China
2.Southern Univ Sci & Technol, Shenzhen Key Lab Cardiovasc Hlth & Precis Med, 1088 Xueyuan Ave, Shenzhen 518055, Peoples R China
3.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen 518055, Peoples R China
4.McGill Univ, Sch Human Nutr, Ste Anne De Bellevue, PQ H9X 3V9, Canada
5.Univ Wisconsin, Sch Nursing, Madison, WI 53705 USA
6.Soochow Univ, Suzhou Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China

Yang, Huan-Huan,Li, Fu-Rong,Chen, Ze-Kun,et al. Duration of Diabetes, Glycemic Control, and Risk of Heart Failure Among Adults With Diabetes: A Cohort Study[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2022,108(5).

Yang, Huan-Huan.,Li, Fu-Rong.,Chen, Ze-Kun.,Zhou, Meng-Ge.,Xie, Li-Feng.,...&Chen, Guo-Chong.(2022).Duration of Diabetes, Glycemic Control, and Risk of Heart Failure Among Adults With Diabetes: A Cohort Study.JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,108(5).

Yang, Huan-Huan,et al."Duration of Diabetes, Glycemic Control, and Risk of Heart Failure Among Adults With Diabetes: A Cohort Study".JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 108.5(2022).