Transition metal-catalyzed enantioselective C–P coupling reactions for the construction of P-stereogenic centers

The transition metal-catalyzed C–P coupling reaction represents an effective strategy for the construction of P-stereogenic centers. These reactions involve different stereochemical mechanistic details depending on the phosphorus starting materials employed. The stereospecific transition metal-catalyzed C–P coupling of enantioenriched P-stereogenic compounds was mainly investigated in the early days. With the development of asymmetric catalysis, corresponding efficient kinetic resolution and dynamic kinetic asymmetric C–P coupling of racemic P-stereogenic starting compounds have recently been disclosed. This perspective discusses the impressive advances and provides an outlook on the directions of further developments.