| 题名 | Bistable insulin response: The win-win solution for glycemic control |
| 作者 | |
| 通讯作者 | Ye，Richard; Liu，Guozhen; Chen，Luonan; Wang，Guanyu |
| 发表日期 | 2022-12-22
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| DOI | |
| 发表期刊 | |
| EISSN | 2589-0042
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| 卷号 | 25期号:12 |
| 摘要 | To satisfy both the safety and rapidity of glycemic control, muscles’ insulin response must be bistable, as theoretically predicted. Here, we test the bistability hypothesis by combining cellular experiments (to measure the threshold values in vitro) with mathematical modeling (to test the relevance of bistability in vivo). We examine bistability in C2C12 myotubes by both single-cell analysis (Fӧrster resonance energy transfer) and cultured cells analysis (immunoblot). These technologies demonstrate bistable insulin response, with typical switch-on and switch-off thresholds of approximately 300 and 100 pM, respectively. Our mathematical model demonstrates the indispensability of bistability in interpreting experimental data, reveals fine details of plasma glucose-insulin dynamics, and explains unclear phenomena. These results suggest that the body's ability to simultaneously avoid both hypoglycemia and hyperglycemia is mediated by bistability. The switch-on threshold is a promising biomarker for metabolic complications due to its deep quantitative connection with body composition, which is easy to measure. |
| 关键词 | |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| 资助项目 | National Natural Science Foundation of China[12131020]
; National Key Research and Development Program of China[2019YFA0906002]
; National Natural Science Foundation of China[22174121]
; National Natural Science Foundation of China[31930022]
; National Natural Science Foundation of China[32070681]
; National Natural Science Foundation of China[61773196]
; Shenzhen Peacock Plan[KQTD2016053117035204]
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| Scopus记录号 | 2-s2.0-85142736595
|
| 来源库 | Scopus
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| 引用统计 |
被引频次[WOS]：5
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/416462 |
| 专题 | 生命科学学院_生物系 生命科学学院 |
| 作者单位 | 1.School of Medicine|Life and Health Sciences,The Chinese University of Hong Kong,Shenzhen,518172,China 2.Center for Endocrinology and Metabolic Diseases,Second Affiliated Hospital,The Chinese University of Hong Kong,Shenzhen,518172,China 3.Guangdong Provincial Key Laboratory of Computational Science and Material Design,Shenzhen,518055,China 4.Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518055,China 5.Department of Biological Sciences,National University of Singapore,Singapore,117558,Singapore 6.Shenzhen Key Laboratory of Gene Regulation and Systems Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518055,China 7.Bio-Sens Tech Pty Ltd,Sydney,2052,Australia 8.Key Laboratory of Systems Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai,200031,China 9.Key Laboratory of Systems Health Science of Zhejiang,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Hangzhou,310024,China 10.West China Biomedical Big Data Center,Med-X Center for Informatics,West China Hospital,Sichuan University,Chengdu,610041,China |
| 第一作者单位 | 生物系; 生命科学学院 |
| 通讯作者单位 | 生物系; 生命科学学院 |
| 推荐引用方式 GB/T 7714 |
Akhtar，Javed,Han，Yukun,Han，Shangchen,et al. Bistable insulin response: The win-win solution for glycemic control[J]. iScience,2022,25(12).
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| APA |
Akhtar，Javed.,Han，Yukun.,Han，Shangchen.,Lin，Weiping.,Cao，Chenyu.,...&Wang，Guanyu.(2022).Bistable insulin response: The win-win solution for glycemic control.iScience,25(12).
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| MLA |
Akhtar，Javed,et al."Bistable insulin response: The win-win solution for glycemic control".iScience 25.12(2022).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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