Microvascular Burden and Incident Heart Failure Among Middle-Aged and Older Adults With Type 1 or Type 2 Diabetes

Li，Fu Rong1,2,3; Hukportie，Daniel Nyarko2; Yang，Jing4,5; Yang，Huan Huan6; Chen，Guo Chong4,7; Wu，Xian Bo2

2022-12-01

10.2337/dc22-0177

Diabetes care   影响因子和分区

1935-5548

OBJECTIVE: To examine the association between microvascular disease (MVD) and risk of heart failure (HF) among individuals with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: We included 1,713 and 28,624 participants with T1DM and T2DM, respectively, from the UK Biobank who were free of HF during enrollment. MVD burden reflected by the presence of retinopathy, peripheral neuropathy, and chronic kidney disease (CKD) at baseline was prospectively evaluated for the association with incidence of HF. Hazard ratios (HRs) and 95% CIs of HF were estimated by Cox regression models adjusted for multiple traditional risk factors. RESULTS: There were 145 and 2,515 incident cases of HF recorded among participants with T1DM and T2DM, respectively, during a median follow-up of 11.5 years. The association between the number of MVD and HF was stronger among participants with T1DM than among those with T2DM (P for interaction <0.001). Compared with participants with no MVD, those with all three MVD had an adjusted HR (95% CI) of 11.37 (5.62, 22.99) in T1DM and 3.66 (2.74, 4.88) in T2DM. In T1DM, HRs (CIs) were 2.69 (1.75, 4.14) for retinopathy, 2.11 (1.38, 3.23) for peripheral neuropathy, and 2.21 (1.53, 3.18) for CKD. The corresponding estimates in T2DM were 1.24 (1.13, 1.36), 1.63 (1.36, 1.96), and 1.73 (1.59, 1.89), respectively. CONCLUSIONS: While a heavier burden of MVD was associated with excess risk of HF both in T1DM and T2DM, the association was evidently more pronounced in T1DM.

英语

NI论文

第一

National Natural Science Foundation of China[82173607];

CLINICAL MEDICINE

2-s2.0-85143199168

Scopus

1.Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine,Southern University of Science and Technology,Shenzhen,China
2.Department of Epidemiology,School of Public Health,Southern Medical University,Guangzhou,China
3.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,China
4.Department of Nutrition and Food Hygiene,School of Public Health,Soochow University,Suzhou,China
5.Department of Clinical Nutrition,First Affiliated Hospital of Soochow University,Suzhou,China
6.Vanke School of Public Health,Tsinghua University,China
7.Department of Epidemiology and Population Health,Albert Einstein College of Medicine,Bronx,United States

Li，Fu Rong,Hukportie，Daniel Nyarko,Yang，Jing,et al. Microvascular Burden and Incident Heart Failure Among Middle-Aged and Older Adults With Type 1 or Type 2 Diabetes[J]. Diabetes care,2022,45(12):2999-3006.

Li，Fu Rong,Hukportie，Daniel Nyarko,Yang，Jing,Yang，Huan Huan,Chen，Guo Chong,&Wu，Xian Bo.(2022).Microvascular Burden and Incident Heart Failure Among Middle-Aged and Older Adults With Type 1 or Type 2 Diabetes.Diabetes care,45(12),2999-3006.

Li，Fu Rong,et al."Microvascular Burden and Incident Heart Failure Among Middle-Aged and Older Adults With Type 1 or Type 2 Diabetes".Diabetes care 45.12(2022):2999-3006.