南方科技大学知识苑(SUSTech KC): N-Trifluoropropylation of Azoles through N-Vinylation and Sequential Hydrogenation

题名	N-Trifluoropropylation of Azoles through N-Vinylation and Sequential Hydrogenation
作者	Chen，Shu Jie 1; Li，Jia Hui 1; He，Zhi Qing 1; Chen，Guo Shu 1; Zhuang，Yin Yin 1; Chen，Chang Ping 1; Liu，Yun Lin 1,2,3
发表日期	2022-11-18
DOI	10.1021/acs.joc.2c02323
发表期刊	JOURNAL OF ORGANIC CHEMISTRY 影响因子和分区
ISSN	0022-3263
EISSN	1520-6904
卷号	87 期号:22页码:15703-15712
摘要	Installing a fluoroalkyl group onto the nitrogen atom of azoles represents a potential strategy for lead optimization in medicinal chemistry. Herein, we describe a method for the N-trifluoropropylation of azoles. This process is accomplished using a combination of regioselective N-vinylation and sequential hydrogenation. The two-step sequence is applicable to a diverse set of azoles and tolerates a wide range of functionalities. In addition, we showcase its practicability and utility through the gram-scale synthesis and the late-stage modification of a complex molecule.
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	其他
WOS记录号	WOS:000882962300001
ESI学科分类	CHEMISTRY
Scopus记录号	2-s2.0-85141997033
来源库	Scopus
引用统计	被引频次[WOS]：7
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/416490
专题	南方科技大学
作者单位	1.School of Chemistry and Chemical Engineering,Guangzhou University,Guangzhou,510006,China 2.State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang,550014,China 3.Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen,518055,China
推荐引用方式 GB/T 7714	Chen，Shu Jie,Li，Jia Hui,He，Zhi Qing,et al. N-Trifluoropropylation of Azoles through N-Vinylation and Sequential Hydrogenation[J]. JOURNAL OF ORGANIC CHEMISTRY,2022,87(22):15703-15712.
APA	Chen，Shu Jie.,Li，Jia Hui.,He，Zhi Qing.,Chen，Guo Shu.,Zhuang，Yin Yin.,...&Liu，Yun Lin.(2022).N-Trifluoropropylation of Azoles through N-Vinylation and Sequential Hydrogenation.JOURNAL OF ORGANIC CHEMISTRY,87(22),15703-15712.
MLA	Chen，Shu Jie,et al."N-Trifluoropropylation of Azoles through N-Vinylation and Sequential Hydrogenation".JOURNAL OF ORGANIC CHEMISTRY 87.22(2022):15703-15712.