MicroRNA-455-3p accelerate malignant progression of tumor by targeting H2AFZ in colorectal cancer

Ye, Lizhen1; Fan, Tingting2; Qin, Ying3; Qiu, Cheng4; Li, Lulu1; Dai, Mengmeng1; Zhou, Yaoyao1; Chen, Yan1,6; Jiang, Yuyang1,2,5,6

2022-12-01

10.1080/15384101.2022.2154549

CELL CYCLE   影响因子和分区

1538-4101

1551-4005

Colorectal cancer (CRC) becomes the second leading cause of cancer-related deaths in 2020. Emerging studies have indicated that microRNAs (miRNAs) play a key role in tumorigenesis and progression. The dysfunctions of miR-455-3p are observed in many cancers. However, its biological function in CRC remains to be confirmed. By sequencing serum sample, miR-455-3p was found to be up-regulated in CRC patients. RT-qPCR demonstrated that the miR-455-3p expression was both higher in the serum and tumor tissues of CRC patients. Furthermore, it indicated that miR-455-3p had the ability in promoting cell proliferation, suppressing cell apoptosis, and stimulating cell migration. In vivo experiments also showed that miR-455-3p promoted tumor growth. Additionally, H2AFZ was proved as the direct gene target of miR-455-3p by dual-luciferase assay. Taken together, miR-455-3p functioned as a tumor promoter in CRC development by regulating H2AFZ directly. Thus, it has enormous potential as a biomarker in the diagnosis of CRC.

miR-455-3p H2AFZ CRC tumor promoter

SCI

英语

通讯

~Department of Science and Technology of Guangdong Province[2017B030314083] ; Shenzhen Progression and Reform Committee[2019156]

Cell Biology

Cell Biology

WOS:000895841700001

TAYLOR & FRANCIS INC

MOLECULAR BIOLOGY & GENETICS

Web of Science

1.Tsinghua Shenzhen Int Grad Sch, State Key Lab Chem Oncogen, Key Lab Chem Biol, Shenzhen, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Dept Chem, Shenzhen, Peoples R China
3.Shenzhen Second Peoples Hosp, Dept Gastrointestinal Surg, Shenzhen, Guangdong, Peoples R China
4.Shenzhen Kivita Innovat Drug Discovery Inst, Tsinghua Shenzhen Int Grad Sch, Natl & Local United Engn Lab Personalized Antitumo, Shenzhen, Guangdong, Peoples R China
5.Tsinghua Univ, Sch Pharmaceut Sci, Beijing, Peoples R China
6.Tsinghua Shenzhen Int Grad Sch, State Key Lab Chem Oncogen, Shenzhen 518055, Guangdong, Peoples R China

Ye, Lizhen,Fan, Tingting,Qin, Ying,et al. MicroRNA-455-3p accelerate malignant progression of tumor by targeting H2AFZ in colorectal cancer[J]. CELL CYCLE,2022,22(7).

Ye, Lizhen.,Fan, Tingting.,Qin, Ying.,Qiu, Cheng.,Li, Lulu.,...&Jiang, Yuyang.(2022).MicroRNA-455-3p accelerate malignant progression of tumor by targeting H2AFZ in colorectal cancer.CELL CYCLE,22(7).

Ye, Lizhen,et al."MicroRNA-455-3p accelerate malignant progression of tumor by targeting H2AFZ in colorectal cancer".CELL CYCLE 22.7(2022).