南方科技大学知识苑(SUSTech KC): Cascade Cross-Coupling/Spirocyclization/Formal [4+2] Cycloaddition Reactions of 3-(2-Isocyanoethyl)Indoles with Aromatic Azides: Access to Polycyclic Spiroindolines Bearing A Pentasubstituted Guanidine Moiety

题名	Cascade Cross-Coupling/Spirocyclization/Formal [4+2] Cycloaddition Reactions of 3-(2-Isocyanoethyl)Indoles with Aromatic Azides: Access to Polycyclic Spiroindolines Bearing A Pentasubstituted Guanidine Moiety
作者	Gu, Man-Zhen 1; Deng, Yan-Qiu 1; Zhang, Xi-Ting 1; Lin, Xiao-Tong 1; Xu, Yi-Bing 1; Hu, Xiao-Wei 1; Liu, Xin-Ni 1; Zheng, Yi-Lin 1; Chen, Guo-Shu 1; Liu, Yun-Lin 1,2,3
通讯作者	Liu, Yun-Lin
发表日期	2022-12-01
DOI	10.1002/adsc.202201168
发表期刊	ADVANCED SYNTHESIS & CATALYSIS 影响因子和分区
ISSN	1615-4150
EISSN	1615-4169
摘要	A rhodium-catalyzed cascade cross-coupling/spirocyclization/formal [4+2] cycloaddition reaction of 3-(2-isocyanoethyl)indoles with aromatic azides is developed, providing a general synthetic protocol to polycyclic spiroindolines bearing a pentasubstituted guanidine moiety with moderate to excellent yields. This transformation is highly effective since one C-C, one C=N, three C-N bonds as well as two new rings are constructed in a single step. More importantly, this work represents a new reactivity pattern of 3-(2-isocyanoethyl)indole, and thus constitutes an valuable addition to 3-(2-isocyanoethyl)indole chemistry.
关键词	3-(2-isocyanoethyl)indoles aromatic azides polycyclic spiroindolines cross-coupling spirocyclization
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	Natural Science Foundation of China["21801050","22171056"] ; Young S&T Talent Training Program of Guangdong Provincial Association for ST(GDSTA), China[SKXRC202206] ; Yangcheng Scholars Research Project of Guangzhou[202235305] ; Featured Innovation Project of Guangdong University[2020KTSCX094] ; Guangdong Natural Science Foundation[2021 A1515010072] ; Open Fund of Guangdong Provincial Key Laboratory of Catalysis[2020B121201002] ; Innovation Research for the Postgraduates of Guangzhou University[2021GDJC-M17] ; University (Institute) Joint Funding (High-level University) Basic Research Project["202102010397","202102010468"] ; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medicial University[QJHKY[2022]389]
WOS研究方向	Chemistry
WOS类目	Chemistry, Applied ; Chemistry, Organic
WOS记录号	WOS:000894055200001
出版者	WILEY-V C H VERLAG GMBH
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/417105
专题	南方科技大学
作者单位	1.Guangzhou Univ, Sch Chem & Chem Engn, 230 Wai Huan Xi Rd, Guangzhou 510006, Peoples R China 2.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China 3.Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China
通讯作者单位	南方科技大学
推荐引用方式 GB/T 7714	Gu, Man-Zhen,Deng, Yan-Qiu,Zhang, Xi-Ting,et al. Cascade Cross-Coupling/Spirocyclization/Formal [4+2] Cycloaddition Reactions of 3-(2-Isocyanoethyl)Indoles with Aromatic Azides: Access to Polycyclic Spiroindolines Bearing A Pentasubstituted Guanidine Moiety[J]. ADVANCED SYNTHESIS & CATALYSIS,2022.
APA	Gu, Man-Zhen.,Deng, Yan-Qiu.,Zhang, Xi-Ting.,Lin, Xiao-Tong.,Xu, Yi-Bing.,...&Liu, Yun-Lin.(2022).Cascade Cross-Coupling/Spirocyclization/Formal [4+2] Cycloaddition Reactions of 3-(2-Isocyanoethyl)Indoles with Aromatic Azides: Access to Polycyclic Spiroindolines Bearing A Pentasubstituted Guanidine Moiety.ADVANCED SYNTHESIS & CATALYSIS.
MLA	Gu, Man-Zhen,et al."Cascade Cross-Coupling/Spirocyclization/Formal [4+2] Cycloaddition Reactions of 3-(2-Isocyanoethyl)Indoles with Aromatic Azides: Access to Polycyclic Spiroindolines Bearing A Pentasubstituted Guanidine Moiety".ADVANCED SYNTHESIS & CATALYSIS (2022).