南方科技大学知识苑(SUSTech KC): Recent Advances in the Study of Na+/K+-ATPase in Neurodegenerative Diseases

题名	Recent Advances in the Study of Na+/K+-ATPase in Neurodegenerative Diseases
作者	Zhang, Xiaoyan1 ; Lee, Weithye 2; Bian, Jin-Song1
通讯作者	Bian, Jin-Song
发表日期	2022-12-01
DOI	10.3390/cells11244075
发表期刊	CELLS 影响因子和分区
EISSN	2073-4409
卷号	11 期号:24
摘要	Na+/K+-ATPase (NKA), a large transmembrane protein, is expressed in the plasma membrane of most eukaryotic cells. It maintains resting membrane potential, cell volume and secondary transcellular transport of other ions and neurotransmitters. NKA consumes about half of the ATP molecules in the brain, which makes NKA highly sensitive to energy deficiency. Neurodegenerative diseases (NDDs) are a group of diseases characterized by chronic, progressive and irreversible neuronal loss in specific brain areas. The pathogenesis of NDDs is sophisticated, involving protein misfolding and aggregation, mitochondrial dysfunction and oxidative stress. The protective effect of NKA against NDDs has been emerging gradually in the past few decades. Hence, understanding the role of NKA in NDDs is critical for elucidating the underlying pathophysiology of NDDs and identifying new therapeutic targets. The present review focuses on the recent progress involving different aspects of NKA in cellular homeostasis to present in-depth understanding of this unique protein. Moreover, the essential roles of NKA in NDDs are discussed to provide a platform and bright future for the improvement of clinical research in NDDs.
关键词	Na+ K+-ATPase neurodegenerative diseases protein-protein interaction mitochondrial dysfunction oxidative stress
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	[82173800] ; [81872865] ; [KQTD20200820113040070]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000900513800001
出版者	MDPI
来源库	Web of Science
引用统计	被引频次[WOS]：14
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/417316
专题	南方科技大学医学院_药理学系南方科技大学医学院
作者单位	1.Southern Univ Sci & Technol, Sch Med, Dept Pharmacol, Shenzhen 518055, Peoples R China 2.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore
第一作者单位	药理学系; 南方科技大学医学院
通讯作者单位	药理学系; 南方科技大学医学院
第一作者的第一单位	药理学系; 南方科技大学医学院
推荐引用方式 GB/T 7714	Zhang, Xiaoyan,Lee, Weithye,Bian, Jin-Song. Recent Advances in the Study of Na+/K+-ATPase in Neurodegenerative Diseases[J]. CELLS,2022,11(24).
APA	Zhang, Xiaoyan,Lee, Weithye,&Bian, Jin-Song.(2022).Recent Advances in the Study of Na+/K+-ATPase in Neurodegenerative Diseases.CELLS,11(24).
MLA	Zhang, Xiaoyan,et al."Recent Advances in the Study of Na+/K+-ATPase in Neurodegenerative Diseases".CELLS 11.24(2022).