南方科技大学知识苑(SUSTech KC): Focusing on the hypoxia-inducible factor pathway: role, regulation, and therapy for osteoarthritis

题名	Focusing on the hypoxia-inducible factor pathway: role, regulation, and therapy for osteoarthritis
作者	Guo, Hanhan 1; Huang, Jianghong 2,3; Liang, Yujie 4; Wang, Daping 1,5; Zhang, Huawei1,6
通讯作者	Liang, Yujie; Wang, Daping; Zhang, Huawei
发表日期	2022-12-12
DOI	10.1186/s40001-022-00926-2
发表期刊	EUROPEAN JOURNAL OF MEDICAL RESEARCH 影响因子和分区
ISSN	0949-2321
EISSN	2047-783X
卷号	27 期号:1
摘要	Osteoarthritis (OA) is a common chronic disabling disease that affects hundreds of millions of people around the world. The most important pathological feature is the rupture and loss of articular cartilage, and the characteristics of avascular joint tissues lead to limited repair ability. Currently, there is no effective treatment to prevent cartilage degeneration. Studies on the mechanism of cartilage metabolism revealed that hypoxia-inducible factors (HIFs) are key regulatory genes that maintain the balance of cartilage catabolism-matrix anabolism and are considered to be the major OA regulator and promising OA treatment target. Although the exact mechanism of HIFs in OA needs to be further clarified, many drugs that directly or indirectly act on HIF signaling pathways have been confirmed by animal experiments and regarded as promising treatments for OA. Targeting HIFs will provide a promising strategy for the development of new OA drugs. This article reviews the regulation of HIFs on intra-articular cartilage homeostasis and its influence on the progression of osteoarthritis and summarizes the recent advances in OA therapies targeting the HIF system.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Guangdong Basic and Applied Basic Research Foundation[GJHZ20190820115203714] ; National Natural Science Foundation of China[2021A1515220134] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials["31900046","81972085","82172465"] ; [2022B1212010003]
WOS研究方向	Research & Experimental Medicine
WOS类目	Medicine, Research & Experimental
WOS记录号	WOS:000897916500001
出版者	BMC
ESI学科分类	CLINICAL MEDICINE
来源库	Web of Science
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/417338
专题	工学院_生物医学工程系
作者单位	1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China 2.Shenzhen Univ, Shenzhen Peoples Hosp 2, Hlth Sci Ctr, Dept Spine Surg & Orthoped,Affiliated Hosp 1, Shenzhen 518035, Peoples R China 3.Tsinghua Univ, Shenzhen Int Grad Sch, Class 9 2020, Shenzhen 518055, Peoples R China 4.Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Dept Child & Adolescent Psychiat, Shenzhen 518020, Peoples R China 5.Shenzhen Univ, Shenzhen Peoples Hosp 2, Guangdong Prov Res Ctr Artificial Intelligence & D, Dept Orthoped,Affiliated Hosp 1,Shenzhen Intellige, Shenzhen 518000, Peoples R China 6.Southern Univ Sci & Technol, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Peoples R China
第一作者单位	生物医学工程系
通讯作者单位	生物医学工程系; 南方科技大学
第一作者的第一单位	生物医学工程系
推荐引用方式 GB/T 7714	Guo, Hanhan,Huang, Jianghong,Liang, Yujie,et al. Focusing on the hypoxia-inducible factor pathway: role, regulation, and therapy for osteoarthritis[J]. EUROPEAN JOURNAL OF MEDICAL RESEARCH,2022,27(1).
APA	Guo, Hanhan,Huang, Jianghong,Liang, Yujie,Wang, Daping,&Zhang, Huawei.(2022).Focusing on the hypoxia-inducible factor pathway: role, regulation, and therapy for osteoarthritis.EUROPEAN JOURNAL OF MEDICAL RESEARCH,27(1).
MLA	Guo, Hanhan,et al."Focusing on the hypoxia-inducible factor pathway: role, regulation, and therapy for osteoarthritis".EUROPEAN JOURNAL OF MEDICAL RESEARCH 27.1(2022).