Experimental and simulation studies of strontium/fluoride-codoped hydroxyapatite nanoparticles with osteogenic and antibacterial activities

Wang, Qun1,2; Li, Pengfei1,5; Tang, Pengfei1; Ge, Xiang3; Ren, Fuzeng4; Zhao, Cancan4; Fang, Ju4; Wang, Kefeng5; Fang, Liming6; Li, Yan7; Bao, Chongyun7; Lu, Xiong1; Duan, Ke8

2019-10

10.1016/j.colsurfb.2019.110359

COLLOIDS AND SURFACES B-BIOINTERFACES   影响因子和分区

0927-7765

1873-4367

Multiple ions codoping may effectively modulate physicochemical and biological properties of hydroxyapatite (HA) for diverse biomedical applications. This study synthesized strontium (Sr)-, fluorine (F)- doped, and Sr/F-codoped HA nanoparticles by a hydrothermal method, and investigated the effect of ion doping on characteristics of HA, including crystallinity, crystal size, lattice parameters, and substitution sites by experiments and simulation with density functional theory (DFT) methods. It was found that, Sr doping increased the lattice parameters of HA whereas F doping decreased these parameters. Additionally, F doping enhanced the structural stability of the Sr-doped HA. F doping created excellent antibacterial properties to effectively inhibit growth of Streptococcus mutans. An appropriate Sr doping level endowed HA with optimum osteogenic ability to promote osteoblastic differentiation of bone marrow stem cells. These suggest that, Sr/F codoping is an effective approach to synthesizing HA-based materials with both antibacterial and osteogenic properties. More broadly, HA nanomaterials with specific characteristics may be designed for meeting diverse requirements from biomedical applications.

Hydroxyapatite Strontium and Fluoride Codoping Antibacterial Osteogenic Density functional theory

SCI ; EI

英语

其他

Teaching Reform Program of Mianyang Teachers' College[Mnu-JY18267]

Biophysics ; Chemistry ; Materials Science

Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials

WOS:000489190200039

ELSEVIER

20193007240688

Crystallinity ; Density functional theory ; Doping (additives) ; Fluorine compounds ; Hydroxyapatite ; Lattice constants ; Lattice theory ; Medical applications ; Nanoparticles ; Physicochemical properties ; Stability ; Stem cells ; Synthesis (chemical)

Biological Materials and Tissue Engineering:461.2 ; Nanotechnology:761 ; Chemical Reactions:802.2 ; Inorganic Compounds:804.2 ; Probability Theory:922.1 ; Mathematical Statistics:922.2 ; Solid State Physics:933 ; Crystal Lattice:933.1.1

BIOLOGY & BIOCHEMISTRY

Web of Science

1.Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China
2.MianYang Teachers Coll, Coll Life Sci & Biotechnol, Mianyang 621006, Sichuan, Peoples R China
3.Tianjin Univ, Sch Mech Engn, Minist Educ, Key Lab Mech Theory & Equipment Design, Tianjin 300072, Peoples R China
4.Southern Univ Sci & Technol China, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China
5.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610065, Sichuan, Peoples R China
6.South China Univ Technol, Sch Mat Sci & Engn, Dept Polymer Sci & Engn, Guangzhou 510641, Guangdong, Peoples R China
7.Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu 610065, Sichuan, Peoples R China
8.Southwest Med Univ, Affiliated Hosp, Dept Bone & Joint Surg, Sichuan Prov Lab Orthopaed Engn, Luzhou 646000, Peoples R China

Wang, Qun,Li, Pengfei,Tang, Pengfei,et al. Experimental and simulation studies of strontium/fluoride-codoped hydroxyapatite nanoparticles with osteogenic and antibacterial activities[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2019,182.

Wang, Qun.,Li, Pengfei.,Tang, Pengfei.,Ge, Xiang.,Ren, Fuzeng.,...&Duan, Ke.(2019).Experimental and simulation studies of strontium/fluoride-codoped hydroxyapatite nanoparticles with osteogenic and antibacterial activities.COLLOIDS AND SURFACES B-BIOINTERFACES,182.

Wang, Qun,et al."Experimental and simulation studies of strontium/fluoride-codoped hydroxyapatite nanoparticles with osteogenic and antibacterial activities".COLLOIDS AND SURFACES B-BIOINTERFACES 182(2019).