| 题名 | The development of novel multifunctional drug system 7,8-DHF@ZIF-8 and its potential application in bone defect healing |
| 作者 | |
| 通讯作者 | Yongmei,Ge; Lijun,Lin; Bin,Tang |
| 共同第一作者 | Qili,Sun; Zhanpeng,Liu; Chao,Xie |
| 发表日期 | 2022-12
|
| DOI | |
| 发表期刊 | |
| ISSN | 0927-7765
|
| EISSN | 1873-4367
|
| 卷号 | 222 |
| 摘要 | Physical exercise has long been considered an essential regulator of bone formation. Recent studies have shown that brain-derived neurotrophic factor (BDNF) is an important cytokine released during physical exercise to promote osteogenic differentiation and facilitate the bone defect healing process. In this study, we developed a multifunctional system 7,8-DHF@ZIF-8, which combines the superior osteogenesis and angiogenesis properties of ZIF-8 and the unique capability of 7,8-DHF to mimic the function of BDNF to compensate for the routine physical exercise missed during the bone defect period. Various material characterizations were performed to confirm the successful synthesis of 7,8-DHF@ZIF-8. Drug release experiments suggested that 7,8-DHF@ZIF-8 could achieve slow diffusive release under physiological conditions within seven days. In vitro cell experiments indicated that low concentrations of ZIF-8 and 7,8-DHF@ZIF-8 could significantly promote the proliferation of MC3T3-E1 cells. Moreover, as proved by RT-QPCR analysis, incorporating 7,8-DHF into ZIF-8 could further enhance osteogenesis and angiogenesis-related gene expression. Therefore, we believe that the multifunctional drug system 7,8-DHF@ZIF-8 should have promising applications to facilitate bone defect healing. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 第一
; 共同第一
; 通讯
|
| 资助项目 | National Key Research and Development Program of China[2019YFA0906004]
; National Foundation of Science and Technology[11872200]
; Guangdong Provincial Key Laboratory of Advanced Bio- materials[2022B1212010003]
; Shenzhen Science and Technology Innovation Committee["KCXFZ20211020174805009","JSGG20200225151916021"]
|
| WOS研究方向 | Biophysics
; Chemistry
; Materials Science
|
| WOS类目 | Biophysics
; Chemistry, Physical
; Materials Science, Biomaterials
|
| WOS记录号 | WOS:000994212500001
|
| 出版者 | |
| EI入藏号 | 20225313323545
|
| EI主题词 | Controlled drug delivery
; Defects
; Polymerase chain reaction
; Sports
; Targeted drug delivery
|
| EI分类号 | Biology:461.9
; Biochemistry:801.2
; Materials Science:951
|
| ESI学科分类 | BIOLOGY & BIOCHEMISTRY
|
| 来源库 | 人工提交
|
| 出版状态 | 在线出版
|
| 引用统计 |
被引频次[WOS]：3
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/420654 |
| 专题 | 工学院_生物医学工程系 工学院_材料科学与工程系 |
| 作者单位 | 1.Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, PR China 2.Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China 3.Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, PR China 4.Guangdong Provincial Key Laboratory of Advanced Biomaterials, PR China |
| 第一作者单位 | 生物医学工程系 |
| 通讯作者单位 | 生物医学工程系 |
| 第一作者的第一单位 | 生物医学工程系 |
| 推荐引用方式 GB/T 7714 |
Qili,Sun,Zhanpeng,Liu,Chao,Xie,et al. The development of novel multifunctional drug system 7,8-DHF@ZIF-8 and its potential application in bone defect healing[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2022,222.
|
| APA |
Qili,Sun.,Zhanpeng,Liu.,Chao,Xie.,Liqiu,Hu.,Huili,Li.,...&Bin,Tang.(2022).The development of novel multifunctional drug system 7,8-DHF@ZIF-8 and its potential application in bone defect healing.COLLOIDS AND SURFACES B-BIOINTERFACES,222.
|
| MLA |
Qili,Sun,et al."The development of novel multifunctional drug system 7,8-DHF@ZIF-8 and its potential application in bone defect healing".COLLOIDS AND SURFACES B-BIOINTERFACES 222(2022).
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