Cell-Derived Vesicles for mRNA Delivery

Li, Zhenghua1,2; Liu, Zhen1,2; Wu, Jiacai1,2,3; Li, Bin1,2,3

2022-12-01

10.3390/pharmaceutics14122699

PHARMACEUTICS   影响因子和分区

1999-4923

The clinical translation of messenger mRNA (mRNA)-based therapeutics requires safe and effective delivery systems. Although considerable progress has been made on the development of mRNA delivery systems, many challenges, such as the dose-limiting toxicity and specific delivery to extrahepatic tissues, still remain. Cell-derived vesicles, a type of endogenous membranous particle secreted from living cells, can be leveraged to load mRNA during or after their biogenesis. Currently, they have received increasing interest for mRNA delivery due to their natural origin, good biocompatibility, cell-specific tropism, and unique ability to cross physiological barriers. In this review, we provide an overview of recent advances in the naturally occurring mRNA delivery platforms and their biomedical applications. Furthermore, the future perspectives on clinical translation of cell-derived vesicles have been discussed.

cell-derived vesicles extracellular vesicles exosome microvesicles mRNA delivery

SCI

英语

第一 ; 通讯

[82072053] ; [RCYX20200714114539061] ; [JCYJ20190806150018265]

Pharmacology & Pharmacy

Pharmacology & Pharmacy

WOS:000903221700001

MDPI

Web of Science

1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Dept Infect Dis, Shenzhen 518020, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen 518020, Peoples R China
3.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China

Li, Zhenghua,Liu, Zhen,Wu, Jiacai,et al. Cell-Derived Vesicles for mRNA Delivery[J]. PHARMACEUTICS,2022,14(12).

Li, Zhenghua,Liu, Zhen,Wu, Jiacai,&Li, Bin.(2022).Cell-Derived Vesicles for mRNA Delivery.PHARMACEUTICS,14(12).

Li, Zhenghua,et al."Cell-Derived Vesicles for mRNA Delivery".PHARMACEUTICS 14.12(2022).