南方科技大学知识苑(SUSTech KC): First Evidence Indicates the Physiology- and Axial-Myopia-Dependent Profiles of Steroid Hormones in Aqueous Humor

题名	First Evidence Indicates the Physiology- and Axial-Myopia-Dependent Profiles of Steroid Hormones in Aqueous Humor
作者	Chou, Tiansheng 1,2; Huang, Xiaosheng 3; Liu, Jiawei 2; Liu, Xinhua 3; Zeng, Kun 3; Yan, Zonghui 3; Mei, Shaoyi 3; Sun, Liangnan 3; Xi, Wenqun 3; Ni, Jinglan 4; Zi, Jin 2; Zhao, Jun 4; Liu, Siqi 1,2
通讯作者	Zhao, Jun; Liu, Siqi
发表日期	2022-12-01
DOI	10.3390/metabo12121220
发表期刊	METABOLITES 影响因子和分区
EISSN	2218-1989
卷号	12 期号:12
摘要	The quantitative level of steroid hormones (SHs) in some body fluids have been accepted for clinical diagnosis, whereas their distribution in aqueous humor (AH) is unknown yet. Herein, a profiling study was conducted with a total of 171 AH and 107 plasma samples using liquid chromatography coupled with tandem mass spectrometry (LC MS/MS). For the first time, six kinds of SHs in AH were quantitatively estimated, and their abundances were ranked at cortisol (F), corticosterone (COR), androstenedione (A2), and 11-deoxycortisol (11DOC). The corresponding abundance of all SHs in AH was significantly lower than those in plasma, while there was a lack of a proportional relationship with the abundance of plasma SHs. Dehydroepiandrosterone sulfate, the most abundant plasma SH, was undetectable in AH, implying that the blood-aqueous barrier might specifically block its transferral. Axial myopia generally results from many factors throughout the entire eye from tissues and molecules; furthermore, the correlation of AH SHs and axial myopia was assessed to look for their indication in such myopia. The panel with five kinds of AH SHs (F, COR, CORT, ALD and A2) was functional as a discriminator for axial myopia and control. The abundance of SHs, therefore, has a specific distribution in AH and can potentially contribute to axial myopia.
关键词	steroid hormone aqueous humor blood-aqueous barrier (BAB) axial length (AL)
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000902730300001
出版者	MDPI
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/420784
专题	南方科技大学第一附属医院
作者单位	1.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China 2.Beijing Genom Inst BGI, Dept Prote, Shenzhen 518000, Peoples R China 3.Jinan Univ, Shenzhen Eye Hosp, Shenzhen Eye Inst, Shenzhen 518040, Peoples R China 4.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen 518020, Peoples R China
通讯作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Chou, Tiansheng,Huang, Xiaosheng,Liu, Jiawei,et al. First Evidence Indicates the Physiology- and Axial-Myopia-Dependent Profiles of Steroid Hormones in Aqueous Humor[J]. METABOLITES,2022,12(12).
APA	Chou, Tiansheng.,Huang, Xiaosheng.,Liu, Jiawei.,Liu, Xinhua.,Zeng, Kun.,...&Liu, Siqi.(2022).First Evidence Indicates the Physiology- and Axial-Myopia-Dependent Profiles of Steroid Hormones in Aqueous Humor.METABOLITES,12(12).
MLA	Chou, Tiansheng,et al."First Evidence Indicates the Physiology- and Axial-Myopia-Dependent Profiles of Steroid Hormones in Aqueous Humor".METABOLITES 12.12(2022).