Modular Engineering of Targeted Dual-Drug Nanoassemblies for Cancer Chemoimmunotherapy

Kang, Tianyi1,5; Li, Yang1; Wang, Yong2; Zhu, Jiao3; Yang, Ling1; Huang, Yulan1; Xiong, Meimei1; Liu, Jinlu1; Wang, Shuai1; Huang, Meijuan3; Wei, Xiawei4; Gou, Maling1

2019-10-09

10.1021/acsami.9b11881

ACS Applied Materials & Interfaces   影响因子和分区

1944-8244

1944-8252

Combination of chemotherapeutics and immunomodulators can generate synergistic anticancer efficacy, exerting efficient chemoimmunotherapy for cancer treatment. Nanoparticulate delivery systems hold great promise to promote synergistic anticancer efficacy for the codelivery of drugs. However, there remain challenges to precisely coencapsulate and deliver combinational drugs at designed ratios due to the difference of compatibility between drugs and nanocarriers. In this study, coassembled nanoparticles of lipophilic prodrugs (LPs) were designed to codeliver chemotherapeutics and immunomodulators for cancer treatment. Such nanoassemblies (NAs) could act as platforms to ratiometrically coencapsulate chemotherapeutics and immunomodulators. Based on this method, NAs formed by the self-assembly of iRGD peptide derivatives, paclitaxel (PTX) LPs, and imiquimod (R837) LPs were demonstrated to target the tumor at unified pharmacokinetics, further inducing the effective tumor inhibition and tumor recurrence prevention. This work provided an alternative to prepare chemoimmunotherapeutic NAs with advantages of ratiometric drug coencapsulation and unified pharmacokinetics, which may advance the future cancer chemoimmunotherapy.

nanoparticles drug delivery chemoimmunotherapy lipophilic prodrug modular engineering breast cancer

SCI ; EI

英语

其他

Science and Technology Project of Chengdu[2018-CY02-00041-GX]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000490357900008

AMER CHEMICAL SOC

20194107521928

Controlled drug delivery ; Diseases ; Drug delivery ; Nanoparticles ; Pharmacokinetics ; Self assembly ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Nanotechnology:761 ; Solid State Physics:933 ; Materials Science:951

Web of Science

1.Sichuan Univ, West China Hosp, State Key Lab Biotherapy & Canc Ctr, Chengdu 610041, Sichuan, Peoples R China
2.Sichuan Univ, West China Hosp, Dept Gastrointestinal Surg, Chengdu 610041, Sichuan, Peoples R China
3.Sichuan Univ, West China Hosp, Dept Thorac Oncol, Chengdu 610041, Sichuan, Peoples R China
4.Sichuan Univ, West China Hosp, State Key Lab Biotherapy & Canc Ctr, Natl Clin Res Ctr Geriatr, Chengdu 610041, Sichuan, Peoples R China
5.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

Kang, Tianyi,Li, Yang,Wang, Yong,et al. Modular Engineering of Targeted Dual-Drug Nanoassemblies for Cancer Chemoimmunotherapy[J]. ACS Applied Materials & Interfaces,2019,11(40):36371-36382.

Kang, Tianyi.,Li, Yang.,Wang, Yong.,Zhu, Jiao.,Yang, Ling.,...&Gou, Maling.(2019).Modular Engineering of Targeted Dual-Drug Nanoassemblies for Cancer Chemoimmunotherapy.ACS Applied Materials & Interfaces,11(40),36371-36382.

Kang, Tianyi,et al."Modular Engineering of Targeted Dual-Drug Nanoassemblies for Cancer Chemoimmunotherapy".ACS Applied Materials & Interfaces 11.40(2019):36371-36382.