Evaluation of the Performance of the Ultrasound (US) Elastographic Q-Analysis Score Combined With the Prostate Imaging Reporting and Data System for Malignancy Risk Stratification in Prostate Nodules Based on Transrectal US-Magnetic Resonance Imaging Fusion Imaging

Ding, Zhimin; Ye, Xiuqin; Zhang, Lei; Sun, Yu; Ni, Zhipeng; Liu, Huiyu; Xu, Jinfeng; Dong, Fajin

2019-11

10.1002/jum.15005

JOURNAL OF ULTRASOUND IN MEDICINE   影响因子和分区

0278-4297

1550-9613

Objectives This study retrospectively evaluated the prognostic performance of the ultrasound elastographic Q-analysis score (EQS) combined with the Prostate Imaging Reporting and Data System (PI-RADS) for malignancy risk stratification in prostate nodules based on transrectal ultrasound-magnetic resonance imaging fusion imaging. Methods Sixty-two patients who were suspected to have PCa between October 2017 and May 2018 in our hospital were retrospectively evaluated. The performance of the EQS and PI-RADS was evaluated by patients' receiver operating characteristic curves in differentiating malignant and benign prostate nodules. The combination of the EQS and PI-RADS methods for prostate imaging was evaluated. Results Sixty-two prostate nodules in 62 patients were included. All of the patients underwent biopsy; 29 cases were prostate cancer, and the rest were benign prostate lesions. Both the EQS and PI-RADS were significantly higher in malignant nodules than in benign nodules. The sensitivity, specificity, area under the curve, positive likelihood ratio, negative likelihood ratio, positive predictive value, negative predictive value, and Youden index of an EQS cutoff of 2.05 were 86.2%, 81.8%, 85.9%, 4.73, 0.169, 80.6%, 87.1%, and 68%, respectively. The corresponding numbers for a PI-RADS cutoff of 4 were 82.7%, 69.7%, 84.2%, 2.72, 0.25, 70.6%, 82.1%, and 52.4%. The "tandem" method had a higher diagnostic specificity (87.9%), positive likelihood ratio (6.55), and positive predictive value (85.1%). The "parallel" method had a higher diagnostic sensitivity (96.5%), negative likelihood ratio (0.06), and negative predictive value (95.2%). Conclusions both the EQS and PI-RADS had good diagnostic performance in differentiating between malignant and benign prostate lesions. The combination of the EQS and PI-RADS improved the diagnostic performance to a certain degree.

diagnostic performance elastographic Q-analysis score parallel prostate biopsy Prostate Imaging Reporting and Data System prostate nodules tandem ultrasound

SCI ; EI

英语

第一 ; 通讯

Commission of Science and Technology of Shenzhen[JCYJ20170307095706970]

Acoustics ; Radiology, Nuclear Medicine & Medical Imaging

Acoustics ; Radiology, Nuclear Medicine & Medical Imaging

WOS:000491035700019

WILEY

20195007811996

Biopsy ; Calcium compounds ; Diseases ; Magnetic resonance imaging ; Risk assessment ; Silicon compounds ; Ultrasonics

Medicine and Pharmacology:461.6 ; Imaging Techniques:746 ; Ultrasonic Waves:753.1 ; Accidents and Accident Prevention:914.1

CLINICAL MEDICINE

Web of Science

Southern Univ Sci & Technol, Affiliated Hosp 1, Jinan Univ, Dept Ultrasound,Clin Coll 2, Shenzhen 518020, Peoples R China

Ding, Zhimin,Ye, Xiuqin,Zhang, Lei,et al. Evaluation of the Performance of the Ultrasound (US) Elastographic Q-Analysis Score Combined With the Prostate Imaging Reporting and Data System for Malignancy Risk Stratification in Prostate Nodules Based on Transrectal US-Magnetic Resonance Imaging Fusion Imaging[J]. JOURNAL OF ULTRASOUND IN MEDICINE,2019,38(11):2991-2998.

Ding, Zhimin.,Ye, Xiuqin.,Zhang, Lei.,Sun, Yu.,Ni, Zhipeng.,...&Dong, Fajin.(2019).Evaluation of the Performance of the Ultrasound (US) Elastographic Q-Analysis Score Combined With the Prostate Imaging Reporting and Data System for Malignancy Risk Stratification in Prostate Nodules Based on Transrectal US-Magnetic Resonance Imaging Fusion Imaging.JOURNAL OF ULTRASOUND IN MEDICINE,38(11),2991-2998.

Ding, Zhimin,et al."Evaluation of the Performance of the Ultrasound (US) Elastographic Q-Analysis Score Combined With the Prostate Imaging Reporting and Data System for Malignancy Risk Stratification in Prostate Nodules Based on Transrectal US-Magnetic Resonance Imaging Fusion Imaging".JOURNAL OF ULTRASOUND IN MEDICINE 38.11(2019):2991-2998.