| 题名 | MALDI-TOF-MS for rapid screening analysis of M-protein in serum |
| 作者 | |
| 通讯作者 | Li, Jie; Liang, Chao; Ji, Ling |
| 发表日期 | 2022-12-15
|
| DOI | |
| 发表期刊 | |
| ISSN | 2234-943X
|
| 卷号 | 12 |
| 摘要 | Monoclonal immunoglobin (M-protein) is a serum biomarker for the diagnosis of plasma cell dyscrasias. Despite limitation of analytical sensitivity and resolution, serum protein electrophoresis and immunofixation electrophoresis are still the front-line tests for the detection of M-proteins. Herein, we developed a MALDI-TOF Mass spectrometry-based method for the screening test of M-proteins in human serum. Based on the unique mass signature of different immunoglobin isotypes, M-Proteins could be rapidly identified and typed. The method demonstrated with high analytical performance and throughput, rapid and simple, which could be a new choice for the diagnosis of plasma cell dyscrasias. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 通讯
|
| 资助项目 | National Natural Science Foundation of China[82104216]
; Guangdong Basic and Applied Basic Research Foundation[2020A1515011450]
; Shenzhen Project of Science and Technology["JCYJ20190809094007719","JCYJ20190809095203586"]
; fund of "Sanming" Project of Medicine in Shenzhen, China[SZSM201812088]
|
| WOS研究方向 | Oncology
|
| WOS类目 | Oncology
|
| WOS记录号 | WOS:000905449300001
|
| 出版者 | |
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：2
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/424640 |
| 专题 | 生命科学学院_生物系 生命科学学院 |
| 作者单位 | 1.Peking Univ, Dept Lab Med, Shenzhen Hosp, Shenzhen, Peoples R China 2.Southern Univ Sci & Technol, Sch Life Sci, Dept Biol, Shenzhen, Peoples R China 3.Hong Kong Baptist Univ, Inst Integrated Bioinfomedicine & Translat Sci IBT, Sch Chinese Med, Hong Kong, Peoples R China 4.Beijing Inst Life, Natl Ctr Prot Sci Beijing, State Key Lab Prote, Beijing, Peoples R China |
| 通讯作者单位 | 生物系; 生命科学学院 |
| 推荐引用方式 GB/T 7714 |
Li, Jie,Xu, Anping,Xie, Weijie,et al. MALDI-TOF-MS for rapid screening analysis of M-protein in serum[J]. Frontiers in Oncology,2022,12.
|
| APA |
Li, Jie.,Xu, Anping.,Xie, Weijie.,Li, Bowen.,Yan, Cunliang.,...&Ji, Ling.(2022).MALDI-TOF-MS for rapid screening analysis of M-protein in serum.Frontiers in Oncology,12.
|
| MLA |
Li, Jie,et al."MALDI-TOF-MS for rapid screening analysis of M-protein in serum".Frontiers in Oncology 12(2022).
|
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
; 
修改评论