The fabrication and evaluation of silver nanoparticle-based keratin scaffolds

Lei, Tongda1; Fan, Jie1,8; Wang, Yongheng2; Cao, Fuyuan3; Yang, Qingqi4; Tian, Faming5; Li, Bo6; Su, Zhibo6; Chen, Rouxi7,9; Liu, Yong1,8

2023

10.1177/08853282221150685

JOURNAL OF BIOMATERIALS APPLICATIONS   影响因子和分区

0885-3282

1530-8022

The biotoxicity caused by focus releasing of Ag, which associated with the Ag loading mode, is a problematic issue that need to be solved for practical utilization of the keratin based wound dressing. In this study, keratin/AgNPs blend scaffolds (Ker/Ag) and keratin scaffolds with AgNPs attached on the scaffold's wall surface (Ag@Ker) were prepared. Structure and physical properties of the scaffolds were tested and investigated. In comparison to the Ag@Ker scaffolds, the Ker/Ag scaffolds with uniform dispersion of AgNPs have larger tensile strength and slower degradation rate. Both kind of scaffolds present excellent antibacterial property with 10 mu g mL(-1) AgNPs addition, while the Ker/Ag displayed a linear Ag releasing ratio in the first 5-7 days, which is beneficial for obtaining a continuous antibacterial property and avoiding the biotoxicity caused by focus release of Ag. Correspondingly, cytotoxicity assay further reveals that the continuously slow release of Ag of the Ker/Ag scaffolds accelerated the proliferation of cell. Infectious animal models and histological studies showed that the Ker/Ag scaffolds can effectively inhibit the inflammatory response and accelerate epithelialization. Thus, it can be concluded that the Ker/Ag scaffolds with uniform dispersion of AgNPs are more attractive as wound repair materials.

loading strategy drug release biocompatibility antibacterial activity wound dressing

SCI ; EI

英语

通讯

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000908088600001

SAGE PUBLICATIONS LTD

20230213371378

Controlled drug delivery ; Degradation ; Dispersions ; Keratin ; Scaffolds (biology) ; Silver nanoparticles ; Targeted drug delivery ; Tensile strength

Biomedical Engineering:461.1 ; Immunology:461.9.1 ; Nanotechnology:761 ; Chemical Reactions:802.2 ; Organic Compounds:804.1 ; Materials Science:951

CLINICAL MEDICINE

Web of Science

1.Tiangong Univ, Sch Text Sci & Engn, Tianjin, Peoples R China
2.North China Univ Sci & Technol, Med Expt Cente, Tangshan, Peoples R China
3.North China Univ Sci & Technol, Lab Anim Ctr, Tangshan, Peoples R China
4.AF Gen Hosp PAL, Dermatol Dept, Beijing, Peoples R China
5.North China Univ Sci & Technol, Med Res Ctr, Tangshan, Peoples R China
6.DongGuan Beyclean Environm Protect Technol Co LTD, Dongguan, Peoples R China
7.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen, Peoples R China
8.Tiangong Univ, Sch Text Sci & Engn, Binshui West Rd 399, Tianjin 300387, Peoples R China
9.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, 1088 Xueyuan Ave, Shenzhen 518055, Peoples R China

Lei, Tongda,Fan, Jie,Wang, Yongheng,et al. The fabrication and evaluation of silver nanoparticle-based keratin scaffolds[J]. JOURNAL OF BIOMATERIALS APPLICATIONS,2023,37(6):1071-1085.

Lei, Tongda.,Fan, Jie.,Wang, Yongheng.,Cao, Fuyuan.,Yang, Qingqi.,...&Liu, Yong.(2023).The fabrication and evaluation of silver nanoparticle-based keratin scaffolds.JOURNAL OF BIOMATERIALS APPLICATIONS,37(6),1071-1085.

Lei, Tongda,et al."The fabrication and evaluation of silver nanoparticle-based keratin scaffolds".JOURNAL OF BIOMATERIALS APPLICATIONS 37.6(2023):1071-1085.