A Super Tough, Rapidly Biodegradable, Ultrafast Hemostatic Bioglue

Wang, Hufei1,2; Cheng, Junyao3; Sun, Feifei4; Dou, Xueyu1; Liu, Jianheng3; Wang, Yiru5; Li, Ming3; Gao, Jianpeng3; Liu, Xiao3; Wang, Xing1,2; Yang, Fei1,2; Zhu, Ziran1,2; Shen, Hong1,2; Zhang, Licheng3; Tang, Peifu3; Wu, Decheng1,6

2023

10.1002/adma.202208622

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

Death happening due to massive hemorrhage has been involved in military conflicts, traffic accidents, and surgical injuries of various human disasters. Achieving rapid and effective hemostasis to save lives is crucial in urgent massive bleeding situations. Herein, a covalent cross-linked AG-PEG glue based on extracellular matrix-like amino-gelatin (AG) and PEG derivatives is developed. The AG-PEG glue gelatinizes fast and exhibits firm and indiscriminate close adhesion with various moist tissues upon being dosed. The formed glue establishes an adhesive and robust barrier to seal the arterial, hepatic, and cardiac hemorrhagic wounds, enabling it to withstand up to 380 mmHg blood pressure in comparison with normal systolic blood pressure of 60-180 mmHg. Remarkably, massive bleeding from a pig cardiac penetrating hole with 6 mm diameter is effectively stopped using the glue within 60 s. Postoperative indexes of the treated pig gradually recover and the cardiac wounds regrow significantly at 14 days. Possessing on-demand solubility, self-gelling, and rapid degradability, the AG-PEG glue may provide a fascinating stop-bleeding approach for clinical hemostasis and emergency rescue.

bioadhesive biodegradable bioglue hemostasis sealants tough hydrogels

SCI ; EI

英语

NI论文

通讯

National Natural Science Foundation of China["21935011~","21725403"] ; Youth Project of Beijing Municipal Natural Science Foundation[2214080] ; Shenzhen Science and Technology Innovation Commission[KQTD20200820113012029]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000915382700001

WILEY-V C H VERLAG GMBH

20230513468565

Blood ; Blood pressure ; Crosslinking ; Gluing ; Heart ; Mammals

Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Chemical Reactions:802.2

MATERIALS SCIENCE

Web of Science

1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100049, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Orthoped Sports Med & Rehabil, Sr Dept Orthoped, Beijing 100853, Peoples R China
4.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Ultrasound, Beijing 100853, Peoples R China
6.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China

Wang, Hufei,Cheng, Junyao,Sun, Feifei,et al. A Super Tough, Rapidly Biodegradable, Ultrafast Hemostatic Bioglue[J]. ADVANCED MATERIALS,2023,35(10).

Wang, Hufei.,Cheng, Junyao.,Sun, Feifei.,Dou, Xueyu.,Liu, Jianheng.,...&Wu, Decheng.(2023).A Super Tough, Rapidly Biodegradable, Ultrafast Hemostatic Bioglue.ADVANCED MATERIALS,35(10).

Wang, Hufei,et al."A Super Tough, Rapidly Biodegradable, Ultrafast Hemostatic Bioglue".ADVANCED MATERIALS 35.10(2023).