Ultrasensitive biosensor based on magnetic microspheres enhanced microfiber interferometer

Kumar，Rahul1,2; Leng，Yuankui3; Liu，Bin1; Zhou，Jun4; Shao，Liyang5; Yuan，Jinhui6; Fan，Xinyu7; Wan，Shengpeng1; Wu，Tao1; Liu，Juan1; Binns，Richard2; Fu，Yong Qing2; Ng，Wai Pang2; Farrell，Gerald8; Semenova，Yuliya8; Xu，Hengyi3; Xiong，Yonghua3; He，Xingdao1; Wu，Qiang1,2

2019-12-01

10.1016/j.bios.2019.111563

BIOSENSORS & BIOELECTRONICS   影响因子和分区

0956-5663

1873-4235

A critical barrier for the successful development of fiber sensors for bio-chemical processes is their limitedly improved sensitivity, restricted by the sensor structural design. To solve this, in this paper, a novel concept was proposed using functionalised modified magnetic microspheres (MMSs) to “amplify” the effect of target bio-chemical analytes to significantly improve the fiber sensor's sensitivity, which has been demonstrated using human chorionic gonadotropin (hCG) as an example. Two types of antibody hCG, (β and α, both can specifically bind with hCG), were adhered on the surface of fibre sensor and MMSs respectively. Both hCG and MMSs will be specifically captured by the fibre sensor, where MMSs act as an “amplifier” to improve the sensor sensitivity. Experimentally immunomagnetic detection limit of 0.0001 mIU/mL has been achieved, which is the highest reported so far. This newly developed methodology opens a new direction for sensitivity improvement and could be further explored to applications require ultrahigh sensitivity detections such as earlier medical diagnostics.

Biosensor Human chorionic gonadotropin (hCG) Optical fiber interferometer Optical fiber sensor

SCI ; EI

英语

其他

National Natural Science Foundation of China[61465009]

Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics

Biophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology

WOS:000495475500032

ELSEVIER ADVANCED TECHNOLOGY

20193907483147

Biosensors ; Diagnosis ; Fiber optic sensors ; Interferometers ; Microspheres ; Optical fibers

Medicine and Pharmacology:461.6 ; Fiber Optics:741.1.2 ; Optical Instruments:941.3

CHEMISTRY

2-s2.0-85072678903

Scopus

1.National Engineering Laboratory for Destructive Testing and Optoelectronic Sensing Technology and ApplicationNanchang HangKong University,Nanchang,330063,China
2.Faculty of Engineering and EnvironmentNorthumbria University,Newcastle Upon Tyne,NE1 8ST,United Kingdom
3.Nanchang UniversityState Key Lab Food Sci & Technol,Nanchang,235 Nanjing East Rd,330047,China
4.Faculty of ScienceInstitute of PhotonicsNingbo University,Ningbo,315211,China
5.Department of Electrical and Electronic EngineeringSouthern University of Science and Technology of China,Shenzhen,China
6.State Key Laboratory of Information Photonics and Optical CommunicationsBeijing University of Posts and Telecommunications,Beijing,China
7.State Key Lab Adv Opt Commun Syst & NetworksShanghai Jiao Tong University,Shanghai,800 Dongchuan Rd,200240,China
8.Photonics Research CentreTechnological University Dublin,Ireland

Kumar，Rahul,Leng，Yuankui,Liu，Bin,et al. Ultrasensitive biosensor based on magnetic microspheres enhanced microfiber interferometer[J]. BIOSENSORS & BIOELECTRONICS,2019,145.

Kumar，Rahul.,Leng，Yuankui.,Liu，Bin.,Zhou，Jun.,Shao，Liyang.,...&Wu，Qiang.(2019).Ultrasensitive biosensor based on magnetic microspheres enhanced microfiber interferometer.BIOSENSORS & BIOELECTRONICS,145.

Kumar，Rahul,et al."Ultrasensitive biosensor based on magnetic microspheres enhanced microfiber interferometer".BIOSENSORS & BIOELECTRONICS 145(2019).