Potential application development of Sr/HCOOH metal organic framework in osteoarthritis

Li，Zhen1,2; Li，Zhenjian1; Li，Sijing5; Wang，Kui1; Ma，Fenbo1; Tang，Bin1,3,4

2019

10.1016/j.micromeso.2019.109835

MICROPOROUS AND MESOPOROUS MATERIALS   影响因子和分区

1387-1811

1873-3093

Metal Organic Frameworks (MOFs) are widely used in various engineering applications, including energy storage, chemical catalysis, etc. However, their potential functions in disease therapy, especially alkaline-earth based MOFs, still need to be developed. In this study, Sr/HCOOH-MOF is successfully prepared and characterized by using XRD, FTIR, TGA, SEM and BET. Drug loading and releasing experiments proved that only 3% ketoprofen was loaded on the Sr/HCOOH-MOF and approximately 80% ketoprofen was released from it after 8 h. Moreover, the potential application of Sr/HCOOH-MOF on attenuating osteoarthritis is evaluated in vitro. Sr/HCOOH-MOF is biocompatible within given doses. Furthermore, it can significantly inhibit the gene expression of IL-1β, iNOS and RANKL. Therefore, Sr/HCOOH-MOF could be a promising compound for attenuating osteoarthritis more than a drug delivery system.

Anti-inflammation Biocompatibility Metal organic framework Strontium

SCI ; EI

英语

第一 ; 通讯

Science, Technology and Innovation Commission of Shenzhen Municipality[]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Applied ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000510087900005

Elsevier B.V.

20194507633544

Alkalinity ; Biocompatibility ; Controlled drug delivery ; Crystalline materials ; Disease control ; Gene expression ; Organic polymers ; Organometallics ; Strontium

Biology:461.9 ; Immunology:461.9.1 ; Alkaline Earth Metals:549.2 ; Chemistry, General:801.1 ; Organic Compounds:804.1 ; Organic Polymers:815.1.1 ; Crystalline Solids:933.1

MATERIALS SCIENCE

2-s2.0-85074394240

Scopus

1.Department of Biomedical EngineeringSouthern University of Science and Technology,Shenzhen,518055,China
2.Department of Physics and Key Laboratory of Artificial Micro- and Nano-structures of Ministry of EducationSchool of Physics and TechnologyWuhan University,Wuhan,430072,China
3.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Guangdong,China
4.Shenzhen Key Laboratory of Cell Microenvironment,Shenzhen,518055,China
5.Department of OrthopedicsZhujiang HospitalSouthern Medical University,Guangzhou,China

Li，Zhen,Li，Zhenjian,Li，Sijing,et al. Potential application development of Sr/HCOOH metal organic framework in osteoarthritis[J]. MICROPOROUS AND MESOPOROUS MATERIALS,2019,294.

Li，Zhen,Li，Zhenjian,Li，Sijing,Wang，Kui,Ma，Fenbo,&Tang，Bin.(2019).Potential application development of Sr/HCOOH metal organic framework in osteoarthritis.MICROPOROUS AND MESOPOROUS MATERIALS,294.

Li，Zhen,et al."Potential application development of Sr/HCOOH metal organic framework in osteoarthritis".MICROPOROUS AND MESOPOROUS MATERIALS 294(2019).