Nickel-Catalyzed Chemoselective Asymmetric Hydrogenation of α,β-Unsaturated Ketoimines: An Efficient Approach to Chiral Allylic Amines

Zhao，Xiang1; Zhang，Feng2; Liu，Kai1; Zhang，Xumu4; Lv，Hui1,3

2019

10.1021/acs.orglett.9b03365

ORGANIC LETTERS   影响因子和分区

1523-7060

1523-7052

An efficient synthetic route to chiral allylic amines has been developed by nickel/(S,S)-Ph-BPE complex catalyzed chemoselective asymmetric hydrogenation of α,β-unsaturated ketoimines. Varieties of α,β-unsaturated ketoimines have been well tolerated in this transformation to give chiral allylic amines with high yields and excellent ee values (up to 99% yield, up to 99% ee). A gram-scale reaction with 0.2 mol % catalyst loading has also been achieved. ©

SCI ; IC ; CCR

英语

NI论文

其他

Natural Science Foundation of Hubei Province[2018CFB430]

Chemistry

Chemistry, Organic

WOS:000497259500022

AMER CHEMICAL SOC

CHEMISTRY

2-s2.0-85074247624

Scopus

1.Key Lab. of Biomed. Poly. of Ministry of Education and College of Chemistry and Molecular SciencesEngineering Research Center of Organosilicon Compounds and MaterialsMinistry of EducationSauvage Center for Molecular ScienecesWuhan University,Wuhan, Hubei,430072,China
2.College of ScienceHunan Agricultural University,Changsha,410128,China
3.Beijing National Laboratory for Molecular SciencesCAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of Sciences,Beijing,100190,China
4.Shenzhen Grubbs Institute and Department of ChemistrySouthern University of Science and Technology,Shenzhen, Guangdong,518055,China

Zhao，Xiang,Zhang，Feng,Liu，Kai,et al. Nickel-Catalyzed Chemoselective Asymmetric Hydrogenation of α,β-Unsaturated Ketoimines: An Efficient Approach to Chiral Allylic Amines[J]. ORGANIC LETTERS,2019,21(22):8966-8969.

Zhao，Xiang,Zhang，Feng,Liu，Kai,Zhang，Xumu,&Lv，Hui.(2019).Nickel-Catalyzed Chemoselective Asymmetric Hydrogenation of α,β-Unsaturated Ketoimines: An Efficient Approach to Chiral Allylic Amines.ORGANIC LETTERS,21(22),8966-8969.

Zhao，Xiang,et al."Nickel-Catalyzed Chemoselective Asymmetric Hydrogenation of α,β-Unsaturated Ketoimines: An Efficient Approach to Chiral Allylic Amines".ORGANIC LETTERS 21.22(2019):8966-8969.