Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biocompatible PLGA-PEG nanocarriers for early detection and treatment of tumours

Liang, Chenghua1; Li, Nan2; Cai, Zikai1; Liang, Rongpu1; Zheng, Xiaoming1; Deng, Li3; Feng, Longbao3; Guo, Rui4; Wei, Bo1

2019-12-04

10.1080/21691401.2019.1687500

Artificial Cells Nanomedicine and Biotechnology   影响因子和分区

2169-1401

2169-141X

At present, cancer is the first cause of death for humans, but early detection and treatment can help improve prognoses and reduce mortality. However, further development of carrier-assistant drug delivery systems (DDSs) is retarded by the aspects such as the low drug-carrying capacity, carrier-induced toxicity and immunogenicity, complex synthesis manipulation. The development of nanoscale drug delivery systems (NDDS) have been rapidly developed to address these issues. In this article, we used PLGA-PEG with good biocompatibility to encapsulate Fe3O4 nanoparticles (a magnetic resonance imaging contrast agent) and DOX (an antitumour drug) via the emulsion-solvent evaporation method, aimed at achieving a dual function of the early detection and the treatment of mammary cancer. The results showed that the Fe3O4/DOX/PLGA-PEG nanoparticles had a relatively uniform size, a high carrier rate of Fe3O4 and high encapsulation efficiency of DOX, and a relatively high activity of released DOX within 120 h. In addition, in vitro studies showed that the Fe3O4/DOX/PLGA-PEG nanoparticles were cytocompatibility in NIH 3T3 fibroblast cells culture study while had a special effect on destroying human breast cancer MCF-7 cells compared with pure DOX solution. In vitro studies revealed that the Fe3O4/DOX/PLGA-PEG enabled enhanced T2 contrast magnetic resonance. Overall, our multifunctional Fe3O4/DOX/PLGA-PEG nanoparticles, composed of biocompatible substances and therapeutic/imaging materials, have great potential for the early detection of cancer and accurate drug delivery via the dynamic monitoring using MRI.

PLGA-PEG nanoparticles Fe3O4 theranostics MRI tumour

SCI ; EI

英语

其他

Science and Technology Project of Guangdong Province[2017A010103009] ; Science and Technology Project of Guangdong Province[2017B020227009] ; Science and Technology Project of Guangdong Province[2015A010101313] ; Science and Technology Project of Guangdong Province[2017A050506011] ; Science and Technology Project of Guangdong Province[2017B090911012] ; Science and Technology Project of Guangdong Province[2018A050506021] ; Science and Technology Project of Guangdong Province[2018A050506019] ; Science and Technology Project of Guangdong Province[2018A050506040]

Biotechnology & Applied Microbiology ; Engineering ; Materials Science

Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000495768900001

TAYLOR & FRANCIS LTD

20194707707387

Biocompatibility ; Cell culture ; Cobalt compounds ; Controlled drug delivery ; Diagnosis ; Diseases ; Emulsification ; Iron oxides ; Magnetic resonance imaging ; Magnetite ; Nanoparticles ; Targeted drug delivery ; Tumors

Bioengineering and Biology:461 ; Magnetism: Basic Concepts and Phenomena:701.2 ; Nanotechnology:761 ; Chemical Operations:802.3 ; Inorganic Compounds:804.2 ; Solid State Physics:933

Web of Science

1.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Gastrointestinal Surg, Guangzhou 510630, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Clin Med Sch 2,Dept Stomatol Ctr,Shenzhen Peoples, Shenzhen, Peoples R China
3.Beogene Biotech Guangzhou CO LTD, Guangzhou, Guangdong, Peoples R China
4.Jinan Univ, Dept Biomed Engn, Guangdong Prov Engn & Technol Res Ctr Drug Carrie, Key Lab Biomat Guangdong Higher Educ Inst, Guangzhou 510632, Guangdong, Peoples R China

Liang, Chenghua,Li, Nan,Cai, Zikai,et al. Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biocompatible PLGA-PEG nanocarriers for early detection and treatment of tumours[J]. Artificial Cells Nanomedicine and Biotechnology,2019,47(1):4211-4221.

Liang, Chenghua.,Li, Nan.,Cai, Zikai.,Liang, Rongpu.,Zheng, Xiaoming.,...&Wei, Bo.(2019).Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biocompatible PLGA-PEG nanocarriers for early detection and treatment of tumours.Artificial Cells Nanomedicine and Biotechnology,47(1),4211-4221.

Liang, Chenghua,et al."Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biocompatible PLGA-PEG nanocarriers for early detection and treatment of tumours".Artificial Cells Nanomedicine and Biotechnology 47.1(2019):4211-4221.