Sympathectomy versus conventional treatment for refractory coronary artery spasm

Lin, Yaowang1; Liu, Huadong1; Yu, Danqing2; Wu, Meishan1; Liu, Qiyun1; Liang, Xinjian1; Pang, Xinli1; Chen, Keqi1; Luo, Linjie1; Dong, Shaohong

2019-09

10.1097/MCA.0000000000000732

CORONARY ARTERY DISEASE   影响因子和分区

0954-6928

1473-5830

Background There is no clear consensus on the potential efficacy and indications for sympathectomy to prevent recurrence of vasospasm in patients with refractory coronary artery spasm (CAS). Objective To compare the clinical outcomes of sympathectomy with those of conventional treatment in patients with refractory CAS. Patients and methods Patients with refractory CAS were randomly assigned to sympathectomy group (n = 37) or conventional treatment group (n = 42). The primary end point was a composite of major adverse cardiac event (MACE) episodes (including cardiac death, nonfatal myocardial infarction, unstable angina, heart failure, and life-threatening arrhythmia), and the secondary end point was death from any cause within 24 months after randomization. Results During the follow-up period of 24 months, the incidence of MACE in the sympathectomy and conventional treatment groups was 16.22 and 61.90%, respectively (P = 0.0001). All-cause death as the secondary end point occurred in zero and six (14.29%) patients, respectively (P = 0.0272). The Kaplan-Meier curve for MACE and all-cause death showed a significant between-group difference (log-rank test, P = 0.0013 and 0.0176, respectively). Conclusion Compared with conventional treatment, sympathectomy significantly reduced the composite end point of MACE episodes and death from any cause in patients with refractory CAS by effectively preventing recurrence of vasospasm.

conventional treatment refractory coronary artery spasm sympathectomy

SCI

英语

第一

Cardiovascular System & Cardiology

Cardiac & Cardiovascular Systems

WOS:000493551800005

LIPPINCOTT WILLIAMS & WILKINS

CLINICAL MEDICINE

Web of Science

1.Jinan Univ, Affiliated Hosp 1, South Univ Sci & Technol, 2nd Clin Med Coll,Shenzhen Peoples Hosp,Dept Card, Shenzhen 518020, Guangdong, Peoples R China
2.Guangdong Acad Sci, Guangdong Gen Hosp, Dept Cardiol, Guangzhou, Guangdong, Peoples R China

Lin, Yaowang,Liu, Huadong,Yu, Danqing,et al. Sympathectomy versus conventional treatment for refractory coronary artery spasm[J]. CORONARY ARTERY DISEASE,2019,30(6):418-424.

Lin, Yaowang.,Liu, Huadong.,Yu, Danqing.,Wu, Meishan.,Liu, Qiyun.,...&Dong, Shaohong.(2019).Sympathectomy versus conventional treatment for refractory coronary artery spasm.CORONARY ARTERY DISEASE,30(6),418-424.

Lin, Yaowang,et al."Sympathectomy versus conventional treatment for refractory coronary artery spasm".CORONARY ARTERY DISEASE 30.6(2019):418-424.