| 题名 | Potential Therapeutic Effects of Mg/HCOOH Metal Organic Framework on Relieving Osteoarthritis |
| 作者 | |
| 通讯作者 | Tang, Bin |
| 发表日期 | 2019-11-14
|
| DOI | |
| 发表期刊 | |
| ISSN | 1860-7179
|
| EISSN | 1860-7187
|
| 卷号 | 15期号:1页码:13-16 |
| 摘要 | This study was designed to explore the potential therapeutic effects of Mg-based metal organic frameworks (MOFs) in osteoarthritis (OA) and to broaden the application field of MOFs. Mg/HCOOH-MOF was introduced and characterized by using SEM, XRD, TGA, and FTIR. ICP-MS results proved that Mg/HCOOH-MOF is stable in various physiological media and can maintain the release of Mg2+ ions for a long time. In vitro experiments were carried out to evaluate its potential application in attenuating OA. Mg/HCOOH-MOF was successfully synthesized, and results of MTT assays showed that it is biocompatible and can promote cell proliferation. qPCR results suggested that it can significantly regulate the expression of OCN, Axin2, iNOS and IL-1 beta, which indicated its activity in anti-inflammation and bone protection. We believe that Mg/HCOOH-MOF could benefit OA therapy. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 第一
; 通讯
|
| 资助项目 | Shenzhen Science and Technology Innovation Committee[JCYJ20170817111312887]
; Shenzhen Science and Technology Innovation Committee[ZDSYS20140509142721429]
|
| WOS研究方向 | Pharmacology & Pharmacy
|
| WOS类目 | Chemistry, Medicinal
; Pharmacology & Pharmacy
|
| WOS记录号 | WOS:000496280400001
|
| 出版者 | |
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：24
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/44739 |
| 专题 | 工学院_生物医学工程系 |
| 作者单位 | 1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China 2.Wuhan Univ, Sch Phys & Technol, Dept Phys, Minist Educ, Wuhan 430072, Hubei, Peoples R China 3.Wuhan Univ, Sch Phys & Technol, Key Lab Artificial Micro & Nanostruct, Minist Educ, Wuhan 430072, Hubei, Peoples R China 4.Guangdong Prov Key Lab Cell Microenvironm & Dis R, Shenzhen 518055, Guangdong, Peoples R China 5.Shenzhen Key Lab Cell Microenvironm, Shenzhen 518055, Peoples R China |
| 第一作者单位 | 生物医学工程系 |
| 通讯作者单位 | 生物医学工程系 |
| 第一作者的第一单位 | 生物医学工程系 |
| 推荐引用方式 GB/T 7714 |
Li, Zhen,Peng, Ying,Pang, Xiangchao,et al. Potential Therapeutic Effects of Mg/HCOOH Metal Organic Framework on Relieving Osteoarthritis[J]. ChemMedChem,2019,15(1):13-16.
|
| APA |
Li, Zhen,Peng, Ying,Pang, Xiangchao,&Tang, Bin.(2019).Potential Therapeutic Effects of Mg/HCOOH Metal Organic Framework on Relieving Osteoarthritis.ChemMedChem,15(1),13-16.
|
| MLA |
Li, Zhen,et al."Potential Therapeutic Effects of Mg/HCOOH Metal Organic Framework on Relieving Osteoarthritis".ChemMedChem 15.1(2019):13-16.
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| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | 操作 | |
| cmdc.201900546.pdf（759KB） | -- | -- | 限制开放 | -- | ||
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