| 题名 | Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment |
| 作者 | |
| 通讯作者 | Tang，Bin |
| 发表日期 | 2019-12-01
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| DOI | |
| 发表期刊 | |
| ISSN | 2045-2322
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| EISSN | 2045-2322
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| 卷号 | 9期号:1 |
| 摘要 | A Sr-based metal-organic framework (MOF) is introduced as ketoprofen carrier to form a comprehensive system for treating osteoarthritis (OA), and the drug loading amount and release rate is investigated. Structural characterization of the samples showed that Sr/PTA-MOF had good crystal morphology and structure, and chemical and thermal stability. Ketoprofen was successfully loaded on the MOF carrier, which had been identified by high performance liquid chromatography (HPLC) and thermogravimetric analysis (TGA). The release experiment manifested that more than 90% of ketoprofen released from Sr/PTA-MOF after 24 h, and ketoprofen delivery was mainly governed by the Higuchi model. Furthermore, cytotoxicity experiment manifested that synthesized MOF carrier had no poisonous effect on OA chondrocytes, which provided a preliminary foundation for the realization of comprehensive treating OA. |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 第一
; 通讯
|
| 资助项目 | Shenzhen Science and Technology Innovation Committee[JCYJ20170817111312887]
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| WOS研究方向 | Science & Technology - Other Topics
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| WOS类目 | Multidisciplinary Sciences
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| WOS记录号 | WOS:000498634600001
|
| 出版者 | |
| Scopus记录号 | 2-s2.0-85075578010
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| 来源库 | Scopus
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| 引用统计 |
被引频次[WOS]：39
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/44789 |
| 专题 | 工学院_生物医学工程系 |
| 作者单位 | 1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China 2.Department of Physics and Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education,School of Physics and Technology,Wuhan University,Wuhan,430072,China 3.Department of Mechanical Engineering,University of Hong Kong,Hong Kong,China 4.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Guangdong,China 5.Shenzhen Key Laboratory of Cell Microenvironment,Shenzhen,518055,China |
| 第一作者单位 | 生物医学工程系 |
| 通讯作者单位 | 生物医学工程系 |
| 第一作者的第一单位 | 生物医学工程系 |
| 推荐引用方式 GB/T 7714 |
Li，Zhen,Peng，Ying,Xia，Xingyu,et al. Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment[J]. Scientific Reports,2019,9(1).
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| APA |
Li，Zhen,Peng，Ying,Xia，Xingyu,Cao，Zhe,Deng，Yuqing,&Tang，Bin.(2019).Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment.Scientific Reports,9(1).
|
| MLA |
Li，Zhen,et al."Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment".Scientific Reports 9.1(2019).
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| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | 操作 | |
| 10.1038@s41598-019-5（1195KB） | -- | -- | 开放获取 | -- | 浏览 | |
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