One-Step Electrodeposition of Multi-element Doped Hydroxyapatite Nanocoating Leading to Enhanced Cytocompatible and Antibacterial Properties of Titanium Implants

Jia, Fenghuan1; Bian, Anqi1; Wu, Zongze6; Li, Meiyu1; Yang, Hao3; Huang, Xiao4; Xie, Lei2; Qiao, Haixia1; Lin, He5; Huang, Yong1,2

2023-01-27

10.1002/slct.202203974

ChemistrySelect   影响因子和分区

2365-6549

The introduction of trace elements into hydroxyapatite (HA) coatings has been widely used for antimicrobial and biocompatible modification of metal implants. In this study, a multifunctional coating of HA co-doped with Cu2+, Zn2+, Sr2+ and F- (CuZnSrFHA) was synthesized on titanium substrate by one-step electrodeposition technology. The CuZnSrFHA consisted of nanoscale needle-like crystals with low roughness and poor hydrophilicity. However, it can continuously release Cu2+, Zn2+ and Sr2+ within 14 days while maintaining good physiological stability. Based on the synergistic effect of Cu and Zn, the CuZnSrFHA coating showed some inhibitory effect on E. coli and S. aureus. Furthermore, the CuZnSrFHA was not significantly cytotoxic and promoted early adhesion and alkaline phosphatase activity of osteoblasts. In conclusion, the multi-element co-doped CuZnSrFHA coating was expected to be a novel surface modification material for the prevention of infectious bone defects.

Antibacterial Cytocompatible Electrodeposition Hydroxyapatite Multi-element doping

SCI

英语

其他

Research Fund for Nature Science Foundation of Hebei province["H2020405015","H2021405041"] ; Young Top-notch Talent Fund of Hebei Province, basic scientific research funding of Hebei Higher Education Institutions["JYT2022017","JYT2022006"] ; Science and Technology Research Project of Hebei Higher Education Institutions["ZD2021007","QN2020247"]

Chemistry

Chemistry, Multidisciplinary

WOS:000919816000001

WILEY-V C H VERLAG GMBH

Web of Science

1.Hebei North Univ, Coll Lab Med, Key Lab Biomed Mat Zhangjiakou, Zhangjiakou 075000, Peoples R China
2.Univ Elect Sci & Technol China, Sch Med, Chengdu 610054, Peoples R China
3.Wuhan Inst Technol, Key Lab Green Chem Proc, Minist Educ, Wuhan 430205, Peoples R China
4.Guangxi Univ Sci & Technol, Sch Phys Educ, Liuzhou 545006, Peoples R China
5.Ludong Univ, Sch Chem & Mat Sci, Yantai 264025, Peoples R China
6.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Intervent Radiol,Clin Med C, Shenzhen 518020, Guangdong, Peoples R China

Jia, Fenghuan,Bian, Anqi,Wu, Zongze,et al. One-Step Electrodeposition of Multi-element Doped Hydroxyapatite Nanocoating Leading to Enhanced Cytocompatible and Antibacterial Properties of Titanium Implants[J]. ChemistrySelect,2023,8(4).

Jia, Fenghuan.,Bian, Anqi.,Wu, Zongze.,Li, Meiyu.,Yang, Hao.,...&Huang, Yong.(2023).One-Step Electrodeposition of Multi-element Doped Hydroxyapatite Nanocoating Leading to Enhanced Cytocompatible and Antibacterial Properties of Titanium Implants.ChemistrySelect,8(4).

Jia, Fenghuan,et al."One-Step Electrodeposition of Multi-element Doped Hydroxyapatite Nanocoating Leading to Enhanced Cytocompatible and Antibacterial Properties of Titanium Implants".ChemistrySelect 8.4(2023).