南方科技大学知识苑(SUSTech KC): The use of multiplex imaging techniques to characterize tuberculous granuloma heterogeneity

题名	The use of multiplex imaging techniques to characterize tuberculous granuloma heterogeneity
作者	Xu, Ruiyao 1; Xiao, Wei 2; Ding, Guanggui 3,4; Zeng, Jiang 5; Liu, Hui 5; Cai, Yi 1; Chen, Xinchun 1
通讯作者	Chen, Xinchun
发表日期	2023-02-01
DOI	10.1002/wsbm.1601
发表期刊	WIREs Mechanisms of Disease 影响因子和分区
ISSN	2692-9368
摘要	Caseous granulomas are pathological hallmarks of tuberculosis (TB), and increasing evidence suggests that TB granuloma composition is highly temporally and spatially heterogenous in both animal models and humans. Traditional pathological techniques are limited in their ability to reveal the heterogeneity present in TB granulomas. Multiplex tissue imaging tools combined with powerful, high resolution spatial analysis have enabled the detection of various cell phenotypes, aiding in the visualization of the granuloma complex and revealing the interactions between immune cells and nonimmune cells. This updated understanding of tuberculous granuloma heterogeneity offers vital insights for researchers aiming to uncover the immunoregulatory mechanisms underlying granuloma formation during TB pathogenesis. More detailed granuloma classification systems will also be of use for precision medicine, and for identifying biological targets for host-directed therapeutics in TB patients.This article is categorized under:Infectious Diseases > Genetics/Genomics/EpigeneticsInfectious Diseases > Biomedical EngineeringInfectious Diseases > Molecular and Cellular Physiology
关键词	heterogeneity multiplex imaging tools tuberculous granuloma
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	Natural Science Foundation of China["82100015","82072252","91942315"] ; Science and Technology Project of Shenzhen["JCY20200109105012589","KCXFZ202002011007083"]
WOS研究方向	Research & Experimental Medicine
WOS类目	Medicine, Research & Experimental
WOS记录号	WOS:000922619400001
出版者	WILEY
来源库	Web of Science
引用统计	被引频次[WOS]：0
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/475092
专题	南方科技大学第一附属医院
作者单位	1.Shenzhen Univ, Sch Med, Dept Pathogen Biol, Guangdong Prov Key Lab Reg Immun & Dis, Shenzhen, Peoples R China 2.Univ Sydney, Fac Med & Hlth, Sch Med Sci, Sydney, NSW, Australia 3.Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1, Clin Med Coll 2,Dept Thorac Surg, Shenzhen, Peoples R China 4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China 5.Fifth Peoples Hosp Ganzhou, Ganzhou, Jiangxi, Peoples R China
推荐引用方式 GB/T 7714	Xu, Ruiyao,Xiao, Wei,Ding, Guanggui,et al. The use of multiplex imaging techniques to characterize tuberculous granuloma heterogeneity[J]. WIREs Mechanisms of Disease,2023.
APA	Xu, Ruiyao.,Xiao, Wei.,Ding, Guanggui.,Zeng, Jiang.,Liu, Hui.,...&Chen, Xinchun.(2023).The use of multiplex imaging techniques to characterize tuberculous granuloma heterogeneity.WIREs Mechanisms of Disease.
MLA	Xu, Ruiyao,et al."The use of multiplex imaging techniques to characterize tuberculous granuloma heterogeneity".WIREs Mechanisms of Disease (2023).