| 题名 | Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer |
| 作者 | |
| 通讯作者 | Jin‑Tang Dong |
| 共同第一作者 | Qingqing Huang; Mingcheng Liu |
| 发表日期 | 2023-02-21
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| DOI | https://doi.org/10.1186/s12916-023-02763-4 |
| 发表期刊 | |
| 摘要 | Castration-resistant prostate cancer often metastasizes to the bone, and such bone metastases eventually become resistant to available therapies, leading to the death of patients. Enriched in the bone, TGF-β plays a pivotal role in bone metastasis development. However, directly targeting TGF-β or its receptors has been challenging for the treatment of bone metastasis. We previously found that TGF-β induces and then depends on the acetylation of transcription factor KLF5 at K369 to regulate multiple biological processes, including the induction of EMT, cellular invasiveness, and bone metastasis. Acetylated KLF5 (Ac-KLF5) and its downstream efectors are thus potential therapeutic targets for treating TGF-β-induced bone metastasis in prostate cancer |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 第一
; 共同第一
; 通讯
|
| 来源库 | 人工提交
|
| 引用统计 |
被引频次[WOS]：0
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/475106 |
| 专题 | 南方科技大学医学院_人类细胞生物和遗传学系 南方科技大学医学院 |
| 作者单位 | 1.Department of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology 2.Department of Urology, Kidney and Urology Center, Pelvic Floor Disorders Center, the Seventh Afliated Hospital, Sun Yat-sen University |
| 第一作者单位 | 人类细胞生物和遗传学系; 南方科技大学医学院 |
| 通讯作者单位 | 人类细胞生物和遗传学系; 南方科技大学医学院 |
| 第一作者的第一单位 | 人类细胞生物和遗传学系; 南方科技大学医学院 |
| 推荐引用方式 GB/T 7714 |
Qingqing Huang,Mingcheng Liu,Duo Zhang,et al. Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer[J]. BMC Medicine,2023.
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| APA |
Qingqing Huang.,Mingcheng Liu.,Duo Zhang.,Bing‑Biao Lin.,Xing Fu.,...&Jin‑Tang Dong.(2023).Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer.BMC Medicine.
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| MLA |
Qingqing Huang,et al."Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer".BMC Medicine (2023).
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| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | 操作 | |
| Nitazoxanide inhibit（4762KB） | -- | -- | 开放获取 | -- | 浏览 | |
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