南方科技大学知识苑(SUSTech KC): Specific deletion of Axin1 leads to activation of beta-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice

题名	Specific deletion of Axin1 leads to activation of beta-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice
作者	Xie, Rong 1; Yi, Dan 2,3; Zeng, Daofu 2; Jie, Qiang 4; Kang, Qinglin 5; Zhang, Zeng 5; Zhang, Zhenlin 6; Xiao, Guozhi7 ; Chen, Lin 8; Tong, Liping 2; Chen, Di 2,3
通讯作者	Tong, Liping; Chen, Di
发表日期	2022-12-21
DOI	10.7554/eLife.80013
发表期刊	eLife 影响因子和分区
ISSN	2050-084X
卷号	11
摘要	Axin1 is a key regulator of canonical Wnt signaling pathway. Roles of Axin1 in skeletal development and in disease occurrence have not been fully defined. Here, we report that Axin1 is essential for lower limb development. Specific deletion of Axin1 in limb mesenchymal cells leads to fibular hemimelia (FH)-like phenotype, associated with tarsal coalition. Further studies demonstrate that FH disease is associated with additional defects in Axin1 knockout (KO) mice, including decreased osteoclast formation and defects in angiogenesis. We then provide in vivo evidence showing that Axin1 controls limb development through both canonical beta-catenin and BMP signaling pathways. We demonstrate that inhibition of beta-catenin or BMP signaling could significantly reverse the FH phenotype in mice. Together, our findings reveal that integration of beta-catenin and BMP signaling by Axin1 is required for lower limb development. Defect in Axin1 signaling could lead to the development of FH disease.
关键词	mice rat human Mouse
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	National Natural Science Foundation of China["82030067","82161160342","82172397","81974320"] ; National Key Research and Development Program of China[2021YFB3800800] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515111075]
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
WOS记录号	WOS:000933081700001
出版者	eLIFE SCIENCES PUBL LTD
来源库	Web of Science
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/489997
专题	南方科技大学医学院
作者单位	1.Rush Univ, Dept Orthoped Surg, Med Ctr, Chicago, IL USA 2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Ctr Comp Aided Drug Discovery, Shenzhen, Peoples R China 3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Fac Pharmaceut Sci, Shenzhen, Peoples R China 4.Xi An Jiao Tong Univ, Honghui Hosp, Coll Med, Dept Orthoped Surg, Xian, Peoples R China 5.Shanghai Jiao Tong Univ, Dept Orthoped Surg, Affiliated Peoples Hosp 6, Shanghai, Peoples R China 6.Shanghai Jiao Tong Univ, Dept Osteoporosis & Bone Dis, Affiliated Peoples Hosp 6, Shanghai, Peoples R China 7.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China 8.Army Med Univ, Daping Hosp, Dept Wound Repair & Rehabil, State Key Lab Trauma & Combined Injury, Chongqing, Peoples R China
推荐引用方式 GB/T 7714	Xie, Rong,Yi, Dan,Zeng, Daofu,et al. Specific deletion of Axin1 leads to activation of beta-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice[J]. eLife,2022,11.
APA	Xie, Rong.,Yi, Dan.,Zeng, Daofu.,Jie, Qiang.,Kang, Qinglin.,...&Chen, Di.(2022).Specific deletion of Axin1 leads to activation of beta-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice.eLife,11.
MLA	Xie, Rong,et al."Specific deletion of Axin1 leads to activation of beta-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice".eLife 11(2022).