| 题名 | Enantioselective construction of triaryl-substituted all-carbon quaternary stereocenters via organocatalytic arylation of oxindoles with azonaphthalenes |
| 作者 | |
| 通讯作者 | Zhang, Junmin; Tan, Bin |
| 发表日期 | 2023-02-01
|
| DOI | |
| 发表期刊 | |
| ISSN | 2041-6520
|
| EISSN | 2041-6539
|
| 卷号 | 14期号:9页码:2330-2335 |
| 摘要 | Azonaphthalenes have been verified as a class of effective arylation reagents in a variety of asymmetric transformations. Here a highly efficient approach to construct triaryl-substituted all-carbon quaternary stereocenters through chiral phosphoric acid-catalyzed enantioselective arylation of 3-aryl-2-oxindoles with azonaphthalenes is disclosed. This chemistry is scalable and displays excellent functional group tolerance, furnishing a series of 3,3-disubstituted 2-oxindole derivatives in good yields with excellent enantiocontrol. Preliminary mechanistic data suggest that the initially formed direct addition intermediate undergoes intramolecular annulation under acidic reaction conditions. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 重要成果 | NI论文
|
| 学校署名 | 通讯
|
| 资助项目 | National Natural Science Foundation of China["21825105","22231004","22271135"]
; National Key R&D Program of China[2021YFF0701604]
; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002]
; Guangdong Innovative Program[2019BT02Y335]
; Shenzhen Science and Technology Program["KQTD20210811090112004","JCYJ20210324120205016","JCYJ20210324105005015"]
|
| WOS研究方向 | Chemistry
|
| WOS类目 | Chemistry, Multidisciplinary
|
| WOS记录号 | WOS:000931173400001
|
| 出版者 | |
| EI入藏号 | 20230913636814
|
| EI主题词 | Aromatic compounds
; Enantioselectivity
; Reaction intermediates
; Stereochemistry
|
| EI分类号 | Chemistry:801
; Physical Chemistry:801.4
; Chemical Products Generally:804
; Organic Compounds:804.1
|
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：4
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/490001 |
| 专题 | 理学院_化学系 深圳格拉布斯研究院 |
| 作者单位 | 1.Shenzhen Univ, Coll Chem & Environm Engn, Coll Phys & Optoelect Engn, Int Joint Res Ctr Mol Sci, Shenzhen 518060, Peoples R China 2.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Dept Chem, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China |
| 第一作者单位 | 化学系; 深圳格拉布斯研究院 |
| 通讯作者单位 | 化学系; 深圳格拉布斯研究院 |
| 推荐引用方式 GB/T 7714 |
Chen, Pengquan,Lv, Mei-Jun,Cheng, Jun Kee,et al. Enantioselective construction of triaryl-substituted all-carbon quaternary stereocenters via organocatalytic arylation of oxindoles with azonaphthalenes[J]. Chemical Science,2023,14(9):2330-2335.
|
| APA |
Chen, Pengquan.,Lv, Mei-Jun.,Cheng, Jun Kee.,Xiang, Shao-Hua.,Ren, Xiang-Zhong.,...&Tan, Bin.(2023).Enantioselective construction of triaryl-substituted all-carbon quaternary stereocenters via organocatalytic arylation of oxindoles with azonaphthalenes.Chemical Science,14(9),2330-2335.
|
| MLA |
Chen, Pengquan,et al."Enantioselective construction of triaryl-substituted all-carbon quaternary stereocenters via organocatalytic arylation of oxindoles with azonaphthalenes".Chemical Science 14.9(2023):2330-2335.
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