A pH responsive and superporous biocomposite hydrogel of Salvia spinosa polysaccharide-co-methacrylic acid for intelligent drug delivery

Ali, Arshad1; Haseeb, Muhammad Tahir2; Hussain, Muhammad Ajaz3; Tulain, Ume Ruqia2; Muhammad, Gulzar4; Azhar, Irfan5; Hussain, Syed Zajif6; Hussain, Irshad6; Ahmad, Naveed7

2023-02-06

10.1039/d2ra05240g

RSC ADVANCES   影响因子和分区

2046-2069

Herein, a drug delivery system (SSH-co-MAA) based on the mucilage from seeds of Salvia spinosa (SSH; polymer) and methacrylic acid (MAA; monomer) is introduced for the controlled delivery of venlafaxine HCl using a sustainable chemical approach. The optimized conditions for the designing of the ideal formulation (M4) of SSH-co-MAA were found to be 2.5% (w/w) of SSH, 30.0% (w/w) of MAA, 0.4% (w/w) of both N,N '-methylene-bis-acrylamide (MBA; cross-linker) and potassium persulfate (KPS; initiator). The structure characterization of SSH-co-MAA by Fourier transform infrared and solid-state CP/MAS C-13-NMR spectroscopy has confirmed the grafting of MAA onto SSH. The thermogravimetric analysis revealed that SSH-co-MAA is a stable entity before and after loading of the venlafaxine HCl-loaded SSH-co-MAA (VSSH-co-MAA). Scanning electron microscopy images of SSH-co-MAA after swelling then freeze drying showed the superporous nature of the hydrogel. The gel fraction (%) of SSH-co-MAA depended upon concentration of SSH, MAA, and MBA. The porosity (%) was increased with the increase in the concentration of SSH and decreased with the decrease in the concentration of MAA and MBA. The swelling indices, venlafaxine HCl loading, and release (24 h at the pH of the gastrointestinal tract) from VSSH-co-MAA were found to be dependent on the pH of the swelling media and the concentration of SSH, MAA, and MBA. The release of venlafaxine HCl followed non-Fickian diffusion mechanism. Conclusively, SSH-co-MAA is a novel material for potential application in targeted drug delivery applications.

SCI ; EI

英语

其他

Chemistry

Chemistry, Multidisciplinary

WOS:000928973900001

ROYAL SOC CHEMISTRY

20230913648171

Amides ; Controlled drug delivery ; Hydrogels ; Nuclear magnetic resonance spectroscopy ; Potassium compounds ; Scanning electron microscopy ; Targeted drug delivery ; Thermogravimetric analysis

Chemistry:801 ; Colloid Chemistry:801.3 ; Chemical Products Generally:804 ; Organic Compounds:804.1

Web of Science

1.Univ Sargodha, Inst Chem, Sargodha 40100, Pakistan
2.Univ Sargodha, Fac Pharm, Sargodha 40100, Pakistan
3.Univ Punjab, Ctr Organ Chem, Sch Chem, Lahore 54590, Pakistan
4.Govt Coll Univ, Dept Chem, Lahore 54000, Pakistan
5.Southern Univ Sci & Technol, Coll Sci, Dept Chem, Shenzhen 518055, Peoples R China
6.Lahore Univ Management Sci, SBA Sch Sci & Engn, Dept Chem, Lahore 54792, Pakistan
7.Jouf Univ, Coll Pharm, Dept Pharmaceut, Sakaka 72388, Saudi Arabia

Ali, Arshad,Haseeb, Muhammad Tahir,Hussain, Muhammad Ajaz,et al. A pH responsive and superporous biocomposite hydrogel of Salvia spinosa polysaccharide-co-methacrylic acid for intelligent drug delivery[J]. RSC ADVANCES,2023,13(8):4932-4948.

Ali, Arshad.,Haseeb, Muhammad Tahir.,Hussain, Muhammad Ajaz.,Tulain, Ume Ruqia.,Muhammad, Gulzar.,...&Ahmad, Naveed.(2023).A pH responsive and superporous biocomposite hydrogel of Salvia spinosa polysaccharide-co-methacrylic acid for intelligent drug delivery.RSC ADVANCES,13(8),4932-4948.

Ali, Arshad,et al."A pH responsive and superporous biocomposite hydrogel of Salvia spinosa polysaccharide-co-methacrylic acid for intelligent drug delivery".RSC ADVANCES 13.8(2023):4932-4948.