南方科技大学知识苑(SUSTech KC): Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade

题名	Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade
作者	Fox，Douglas B.1; Ebright，Richard Y.1; Hong，Xin1,8 ; Russell，Hunter C.1; Guo，Hongshan 1,9; LaSalle，Thomas J.1,2; Wittner，Ben S.1; Poux，Nicolas 1; Vuille，Joanna A.1; Toner，Mehmet 3,4,5; Hacohen，Nir 1,2; Boland，Genevieve M.1,5; Sen，Debattama R.1,6; Sullivan，Ryan J.1,6; Maheswaran，Shyamala 1,5
通讯作者	Maheswaran，Shyamala
共同第一作者	Ebright，Richard Y.; Hong，Xin; Russell，Hunter C.
发表日期	2023-12-01
DOI	10.1038/s41698-023-00362-3
发表期刊	npj Precision Oncology 影响因子和分区
EISSN	2397-768X
卷号	7 期号:1
摘要	Immune checkpoint blockade (ICB) has demonstrated efficacy in patients with melanoma, but many exhibit poor responses. Using single cell RNA sequencing of melanoma patient-derived circulating tumor cells (CTCs) and functional characterization using mouse melanoma models, we show that the KEAP1/NRF2 pathway modulates sensitivity to ICB, independently of tumorigenesis. The NRF2 negative regulator, KEAP1, shows intrinsic variation in expression, leading to tumor heterogeneity and subclonal resistance.
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	共同第一 ; 其他
资助项目	NIH["T32CA009216","1F30CA232407-01","RO1CA129933","2U01EB012493","5U01EB012493","5P41EB002503"] ; National Institute of General Medical Sciences[T32GM007753] ; Adelson Medical Research Foundation[U54CA224068]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000942856800001
出版者	NATURE PORTFOLIO
Scopus记录号	2-s2.0-85149593434
来源库	Scopus
引用统计	被引频次[WOS]：8
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/497511
专题	南方科技大学医学院_生物化学系南方科技大学医学院
作者单位	1.Massachusetts General Hospital Cancer Center and Harvard Medical School,Boston,02114,United States 2.Broad Institute of Harvard and MIT,Cambridge,02139,United States 3.Center for Engineering in Medicine,Massachusetts General Hospital and Harvard Medical School,Boston,02114,United States 4.Shriners Hospitals for Children,Boston,02114,United States 5.Department of Surgery,Massachusetts General Hospital and Harvard Medical School,Boston,02114,United States 6.Department of Medicine,Massachusetts General Hospital and Harvard Medical School,Boston,02114,United States 7.Howard Hughes Medical Institute,Bethesda,20815,United States 8.Department of Biochemistry,School of Medicine and Key University Laboratory of Metabolism and Health of Guangdong,Southern University of Science and Technology,Shenzhen,518055,China 9.Liangzhu Laboratory,Zhejiang University Medical Center,Hangzhou,311121,China
推荐引用方式 GB/T 7714	Fox，Douglas B.,Ebright，Richard Y.,Hong，Xin,et al. Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade[J]. npj Precision Oncology,2023,7(1).
APA	Fox，Douglas B..,Ebright，Richard Y..,Hong，Xin.,Russell，Hunter C..,Guo，Hongshan.,...&Maheswaran，Shyamala.(2023).Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade.npj Precision Oncology,7(1).
MLA	Fox，Douglas B.,et al."Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade".npj Precision Oncology 7.1(2023).

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