Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer?s Disease and Parkinson?s Disease

Yang, Jing1,2,3,4; Zhang, Wei1,2,3,4; Zhang, Shugeng5; Iyaswamy, Ashok6; Sun, Jichao1,2,3,4; Wang, Jigang1,2,3,4,7; Yang, Chuanbin1,2,3,4

2022-12-01

10.14336/AD.2022.0927

Aging and Disease   影响因子和分区

2152-5250

A key pathological feature of neurodegenerative diseases (NDs) such as Alzheimer's disease (AD) and Parkinson's disease (PD) is the accumulation of aggregated and misfolded protein aggregates with limited effective therapeutic agents. TFEB (transcription factor EB), a key regulator of lysosomal biogenesis and autophagy, plays a pivotal role in the degradation of protein aggregates and has thus been regarded as a promising therapeutic target for these NDs. Here, we systematically summarize the molecular mechanisms and function of TFEB regulation. We then discuss the roles of TFEB and autophagy-lysosome pathways in major neurodegenerative diseases including AD and PD. Finally, we illustrate small molecule TFEB activators with protective roles in NDs animal models, which show great potential for being further developed into novel antineurodegenerative agents. Overall, targeting TFEB for enhancing lysosomal biogenesis and autophagy may represent a promising opportunity for the discovery of disease-modifying therapeutics for neurodegenerative disorders though more in-depth basic and clinical studies are required in the future.

TFEB (transcription factor EB) lysosome autophagy neurodegenerative disease Alzheimer?s disease Parkinson?s disease

SCI

英语

通讯

National Natural Science Foundation of China["82003721","81902787","82071193","32000673"] ; National Key Research and Development Program of China[2020YFA0908000] ; Shenzhen Science and Technology Innovation Commission["JCYJ20210324114014039","JCYJ2021032 4115800001","RCYX20210706092040044"] ; China Postdoctoral Science Foundation[2020M683182] ; Guangdong Basic and Applied Basic Research Foundation[2020A1515110549]

Geriatrics & Gerontology

Geriatrics & Gerontology

WOS:000938194300001

INT SOC AGING & DISEASE

Web of Science

1.Shenzhen Peoples Hosp, Dept Geriatr, Shenzhen, Peoples R China
2.Shenzhen Peoples Hosp, Shenzhen Clin Res Ctr Geriatr, Shenzhen, Peoples R China
3.Jinan Univ, Clin Med Coll 2, Shenzhen, Peoples R China
4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China
5.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Hepatobiliary Surg, Div Life Sci & Med,Anhui Prov Key Lab Hepatopancre, Hefei, Peoples R China
6.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Peoples R China
7.China Acad Chinese Med Sci, Inst Chinese Mat Med, Artemisinin Res Ctr, Beijing, Peoples R China

Yang, Jing,Zhang, Wei,Zhang, Shugeng,et al. Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer?s Disease and Parkinson?s Disease[J]. Aging and Disease,2022,14(3).

Yang, Jing.,Zhang, Wei.,Zhang, Shugeng.,Iyaswamy, Ashok.,Sun, Jichao.,...&Yang, Chuanbin.(2022).Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer?s Disease and Parkinson?s Disease.Aging and Disease,14(3).

Yang, Jing,et al."Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer?s Disease and Parkinson?s Disease".Aging and Disease 14.3(2022).