| 题名 | A simple strategy for the efficient design of mitochondria-targeting NIR-II phototheranostics |
| 作者 | |
| 通讯作者 | Li, Yuanyuan; Duo, Yanhong; Tang, Ben Zhong |
| 发表日期 | 2023-02-01
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| DOI | |
| 发表期刊 | |
| ISSN | 2050-750X
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| EISSN | 2050-7518
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| 卷号 | 11期号:12 |
| 摘要 | The pursuit of phototheranostic agents with near-infrared II (NIR-II) emission, high photothermal conversion efficiency (PCE) and the robust generation of reactive oxygen species (ROS) in the aggregated state is always in high demand but remains a big challenge. Herein, we report a simple strategy to endow molecules with NIR-II imaging and photothermal therapy (PTT)/photodynamic therapy (PDT) abilities by equipping NIR-II aggregation-induced emission luminogens (AIEgens) with the cationic trimethylammonium unit, named as TDTN+. The resultant TDTN+ species can self-assemble into nanoparticles, which exhibit a maximum emission at similar to 1052 nm, a high PCE (66.7%), type I and type II ROS generation and a mitochondria-targeting ability, simultaneously. The TDTN+ can realize brain imaging with bright fluorescence and an effective tumor killing effect. Overall, this work presents an innovative design strategy to develop multimodality phototheranostic agents. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| 资助项目 | National Key Research and Development Program of China[2021YFC2600202]
; National Natural Science Foundation of China[32102642]
; Innovation and Technology Commission[ITC-CNERC14SC01]
; Research Grant Council of Hong Kong["16306620","16303221"]
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| WOS研究方向 | Materials Science
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| WOS类目 | Materials Science, Biomaterials
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| WOS记录号 | WOS:000940747100001
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：7
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/501481 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Jilin Univ, Coll Vet Med, Key Lab Zoonosis Res, Minist Educ, Changchun, Peoples R China 2.Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden 3.Zhejiang Univ, Coll Opt Sci & Engn, Int Res Ctr Adv Photon, State Key Lab Modern Opt Instrumentat,Ctr Opt & El, Hangzhou 310058, Peoples R China 4.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Plast Surg, Wuhan 430030, Peoples R China 5.Flinders Univ S Australia, Inst Nanoscale Sci & Technol, Coll Sci & Engn, Adelaide, SA 5042, Australia 6.Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China 7.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Radiat Oncol,Clin Med Coll, Shenzhen 518020, Guangdong, Peoples R China |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Li, Yuanyuan,He, Mubin,Liu, Zeming,et al. A simple strategy for the efficient design of mitochondria-targeting NIR-II phototheranostics[J]. Journal of Materials Chemistry B,2023,11(12).
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| APA |
Li, Yuanyuan.,He, Mubin.,Liu, Zeming.,Chuah, Clarence.,Tang, Youhong.,...&Tang, Ben Zhong.(2023).A simple strategy for the efficient design of mitochondria-targeting NIR-II phototheranostics.Journal of Materials Chemistry B,11(12).
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| MLA |
Li, Yuanyuan,et al."A simple strategy for the efficient design of mitochondria-targeting NIR-II phototheranostics".Journal of Materials Chemistry B 11.12(2023).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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