Fabrication of Porous Tantalum with Low Elastic Modulus and Tunable Pore Size for Bone Repair

Liang, Dingshan1,2; Zhong, Chuanxin1,3; Jiang, Feilong1; Liao, Junchen1; Ye, Haixia1; Ren, Fuzeng1

2023-02-01

10.1021/acsbiomaterials.2c01239

ACS Biomaterials Science & Engineering   影响因子和分区

2373-9878

Porous tantalum (Ta) is a potential bone substitute due to its excellent biocompatibility and desirable mechanical properties. In this work, a series of porous Ta materials with interconnected micropores and varying pore sizes from 23 to 210 mu m were fabricated using spark plasma sintering. The porous structure was formed by thermal decomposition of ammonium bicarbonate powder premixed in the Ta powder. The pore size and porosity were controlled by the categorized particle size of ammonium bicarbonate. The porous Ta has elastic moduli in the range of 2.1-3.2 GPa and compressive yield strength in the range of 23-34 MPa, which are close to those of human bone. In vitro, as-fabricated porous Ta demonstrates excellent biocompatibility by supporting adhesion and proliferation of preosteoblasts. In vivo studies also validate its bone repair capability after implantation in a rat femur defect model. The study demonstrates a facile strategy to fabricate porous Ta with controllable pore size for bone repair.

porous tantalum scaffold bone repair osteogenesis interconnected pore structure orthopedic implant

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China[52122102] ; Basic and Applied Basic Research Fundation of Guangdong Province[2022B1515120082]

Materials Science

Materials Science, Biomaterials

WOS:000930704800001

AMER CHEMICAL SOC

20230813622896

Biocompatibility ; Bone ; Decomposition ; Elastic moduli ; Fabrication ; Particle size ; Pore size ; Repair ; Scaffolds (biology) ; Spark plasma sintering

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Immunology:461.9.1 ; Chemical Reactions:802.2 ; Maintenance:913.5 ; Physical Properties of Gases, Liquids and Solids:931.2 ; Materials Science:951

Web of Science

1.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
2.Hong Kong Univ Sci & Technol, Dept Mech & Aerosp Engn, Kowloon, Hong Kong 999077, Peoples R China
3.Hong Kong Baptist Univ, Law Sau Fai Inst Adv Translat Med Bone & Joint Dis, Sch Chinese Med, Kowloon, Hong Kong 999077, Peoples R China

Liang, Dingshan,Zhong, Chuanxin,Jiang, Feilong,et al. Fabrication of Porous Tantalum with Low Elastic Modulus and Tunable Pore Size for Bone Repair[J]. ACS Biomaterials Science & Engineering,2023,9(3):1720-1728.

Liang, Dingshan,Zhong, Chuanxin,Jiang, Feilong,Liao, Junchen,Ye, Haixia,&Ren, Fuzeng.(2023).Fabrication of Porous Tantalum with Low Elastic Modulus and Tunable Pore Size for Bone Repair.ACS Biomaterials Science & Engineering,9(3),1720-1728.

Liang, Dingshan,et al."Fabrication of Porous Tantalum with Low Elastic Modulus and Tunable Pore Size for Bone Repair".ACS Biomaterials Science & Engineering 9.3(2023):1720-1728.