Functionalized Ionic Liquid Exfoliated MoS2 Nanosheets for Photoacoustic Imaging Guided Synergistic Photothermal/Chemotherapy

Lu, Beibei1,2,3,4,5,6; Hu, Shunyou5,6; Wu, Chengyu5,6; Zhang, Jichuan2,3,4,5,6; Zhang, Jianglin1; Zhang, Jiaheng7

2023-02-01

10.1002/adtp.202200277

ADVANCED THERAPEUTICS   影响因子和分区

2366-3987

Nanosheets exhibit highly specific recognition and can be effectively enriched in tumor cells. Controlling nanosheet size and reducing its potential toxicity are key issues in the photothermal therapy of tumors. Herein, a multifunctional nanoplatform based on molybdenum disulfide (MoS2) is developed using a green solvent with antitumor activity, ionic liquid (IL) exfoliation, and surface modification to prepare a few layers of IL-MoS2 nanosheets, with a lateral dimension of approximate to 96 nm and thickness of 4 nm. The PEG-b-PIL polymer improves the biocompatibility, physiological stability, and biodegradability of the nanosheet, and IL-MoS2-PEG-b-PIL exhibits good photothermal stability and photothermal effects. The in vitro and in vivo results show that IL-MoS2-PEG-b-PIL nanosheets synergistically inhibit tumor cell growth in combination with photothermal therapy and chemotherapy under 808 nm laser irradiation. The steady increase in the weight of mice during the treatment indicates that the nanosheets are safe. Therefore, the results confirm that IL-MoS2-PEG-b-PIL nanosheets exhibit good antitumor effects and provide a promising strategy for clinical cancer treatments.

Ionic liquid MoS2 nanosheets photothermal therapy synergy therapy

SCI

英语

其他

National Natural Science Foundation of China["82073018","21703218"] ; Shenzhen Science and Technology Innovation Committee["JCYJ20180507183907224","KQTD20170809110344233"] ; Economic, Trade and Information Commission of Shenzhen Municipality through the Graphene Manufacture Innovation Center[201901161514] ; Guangdong Province Covid-19 Pandemic Control Research Fund[2020KZDZX1220]

Pharmacology & Pharmacy

Pharmacology & Pharmacy

WOS:000942675900001

WILEY

Web of Science

1.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Dermatol, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.Natl Clin Res Ctr Skin Dis, Candidate Branch, Shenzhen 518020, Guangdong, Peoples R China
4.Peoples Hosp Geriatr Ctr, Dept Shenzhen, Shenzhen 518020, Guangdong, Peoples R China
5.Harbin Inst Technol Shenzhen, Sauvage Lab Smart Mat, Shenzhen 518055, Peoples R China
6.Harbin Inst Technol Shenzhen, Res Ctr Printed Flexible Elect, Sch Mat Sci & Engn, Shenzhen 518055, Peoples R China
7.Univ Idaho, Dept Chem, Moscow, ID 83844 USA

Lu, Beibei,Hu, Shunyou,Wu, Chengyu,et al. Functionalized Ionic Liquid Exfoliated MoS2 Nanosheets for Photoacoustic Imaging Guided Synergistic Photothermal/Chemotherapy[J]. ADVANCED THERAPEUTICS,2023,6(4).

Lu, Beibei,Hu, Shunyou,Wu, Chengyu,Zhang, Jichuan,Zhang, Jianglin,&Zhang, Jiaheng.(2023).Functionalized Ionic Liquid Exfoliated MoS2 Nanosheets for Photoacoustic Imaging Guided Synergistic Photothermal/Chemotherapy.ADVANCED THERAPEUTICS,6(4).

Lu, Beibei,et al."Functionalized Ionic Liquid Exfoliated MoS2 Nanosheets for Photoacoustic Imaging Guided Synergistic Photothermal/Chemotherapy".ADVANCED THERAPEUTICS 6.4(2023).