南方科技大学知识苑(SUSTech KC): Transient receptor potential vanilloid type 4 (TRPV4) promotes tumorigenesis via NFAT4 activation in nasopharyngeal carcinoma

题名	Transient receptor potential vanilloid type 4 (TRPV4) promotes tumorigenesis via NFAT4 activation in nasopharyngeal carcinoma
作者	Zhang, Peng 1,2; Li, Ke 1,2; Wang, Zhen 1,2; Wu, Yongjin 1,2; Zhang, Hua 1,2; Ma, Fang 1,2; Liu, Xiao-Yu3,4 ; Tong, Michael C. F.5; Ru, Xiaochen 6; Zhang, Xiangmin 1,2; Zeng, Xianhai 1,2
通讯作者	Zhang, Peng; Zhang, Xiangmin; Zeng, Xianhai
发表日期	2022-12-22
DOI	10.3389/fmolb.2022.1064366
发表期刊	FRONTIERS IN MOLECULAR BIOSCIENCES 影响因子和分区
EISSN	2296-889X
卷号	9
摘要	Transient receptor potential vanilloid type 4 (TRPV4) can function as an oncogene or tumor suppressor depending on the tumor types. However, little is known regarding the effect of TRPV4 in nasopharyngeal carcinoma (NPC), a highly prevalent malignancy in Southern China and Southeast Asia. We found that TRPV4 mRNA and protein levels were significantly upregulated in NPC tissues. In addition, activation of TRPV4 in NPC cell lines using GSK1016790A (100 nM) induced a Ca2+ influx, whereas pharmacological inhibition or gene knockdown of TRPV4 reduced the proliferation rates of NPC cells. TRPV4 knockdown also decreased the growth of tumor xenografts in vivo. Mechanistically, TRPV4-mediated tumorigenesis is dependent on the activation of Ca2+/calcineurin/calcineurin-nuclear factor of activated T cell 4 (NFAT4) signaling. Furthermore, NFAT4 protein level was overexpressed in NPC tissues and correlated positively with TRPV4. Taken together, TRPV4 promotes the malignant potential of NPC cells by activating NFAT4 signaling. Our findings highlight TRPV4-NFAT4 axis as a potential therapeutic target in NPC.
关键词	nasopharyngeal carcinoma TRPV4 tumorigenesis NFAT4 calcium
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000944040200001
出版者	FRONTIERS MEDIA SA
来源库	Web of Science
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/502144
专题	南方科技大学医学院
作者单位	1.Longgang Otorhinolaryngol Hosp, Shenzhen, Guangdong, Peoples R China 2.Shenzhen Inst Otorhinolaryngol, Shenzhen Key Lab Otorhinolaryngol, Shenzhen, Guangdong, Peoples R China 3.Southern Univ Sci & Technol, Sch Med, Shenzhen, Guangdong, Peoples R China 4.Shenzhen Middle Sch, Shenzhen, Guangdong, Peoples R China 5.Chinese Univ Hong Kong, Dept Otorhinolaryngol Head & Neck Surg, Hong Kong, Peoples R China 6.Huzhou Univ, Sch Med & Nursing, Huzhou, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Peng,Li, Ke,Wang, Zhen,et al. Transient receptor potential vanilloid type 4 (TRPV4) promotes tumorigenesis via NFAT4 activation in nasopharyngeal carcinoma[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2022,9.
APA	Zhang, Peng.,Li, Ke.,Wang, Zhen.,Wu, Yongjin.,Zhang, Hua.,...&Zeng, Xianhai.(2022).Transient receptor potential vanilloid type 4 (TRPV4) promotes tumorigenesis via NFAT4 activation in nasopharyngeal carcinoma.FRONTIERS IN MOLECULAR BIOSCIENCES,9.
MLA	Zhang, Peng,et al."Transient receptor potential vanilloid type 4 (TRPV4) promotes tumorigenesis via NFAT4 activation in nasopharyngeal carcinoma".FRONTIERS IN MOLECULAR BIOSCIENCES 9(2022).