Neutrophil Membrane-Coated Mesoporous Silica Nanoparticles Loaded with Hydrocortisone Alleviate DSS-Induced Colitis in Mice

Wang, Guozhen1; Qi, Yongshuai2; Xu, Jia3; Huang, Yun4; Xiong, Feng1; Huang, Weichang5; Ma, Xiaoxin1; Wang, Shuanghu; Wang, Changxiong6; Zhou, Yunfang3; Wang, Lisheng1

2023-02-01

10.1021/acsanm.2c04615

ACS APPLIED NANO MATERIALS   影响因子和分区

2574-0970

The incidence and prevalence of ulcerative colitis (UC) are increasing worldwide. Hydrocortisone enema (HC) is widely used in UC treatment; however, this approach is limited by the easy degradation of HC in the intestinal environment and low intestinal uptake efficiency. Accordingly, the development of methods to improve the targeting efficiency of corticosteroids is an important issue. Mesoporous silica nanoparticles (MSN) and biomimetic nanovesicles (derived from the natural cell membrane structure) provide a basis for improved drug delivery and uptake. In this research, we constructed neutrophil membrane-coated MSN loaded with HC for the treatment of UC. MSN-HC and neutrophil-derived membrane nanoparticles (MSN-HC@NM NPs) were obtained by mechanical extrusion and characterized. The effects of free HC, MSN, MSN-HC, and MSN-HC@NM NPs were compared using dextran sodium sulfate (DSS)-induced colitis model, including terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assays and inflammatory factors in colon tissues. The MSN-HC@NM NPs alleviated DSS-induced colitis by reducing colon apoptosis and ameliorating the destruction of the colonic barrier and inflammation in mice. This research provides a hydrocortisone delivery system with good biosafety and the potential for clinical translation.

ulcerative colitis hydrocortisone mesoporous silica nanoparticles neutrophil membrane nanoparticles dextran sulfate sodium

SCI

英语

第一 ; 通讯

Key Research and Development Project of Lishui["2021ZDYF13","2021ZDYF15","2022ZDYF23"] ; Joint Funds for the innovation of science and Technology, Fujian province[2021Y9102] ; Shenzhen Science and Technology Project[JCYJ20210324112807021] ; Youth Fund of National Natural Science Foundation of China[81800544]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000937724700001

AMER CHEMICAL SOC

Web of Science

1.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Gastroenterol,Clin Med Coll, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Med Univ, Nanfang Hosp, Dept Nucl Med, Guangzhou 510515, Peoples R China
3.Wenzhou Med Univ, Affiliated Hosp 6, Peoples Hosp Lishui, Lab Clin Pharm, Lishui 323000, Zhejiang, Peoples R China
4.Fujian Med Univ, Affiliated Hosp 1, Depatment Gen Med, Fuzhou 350005, Peoples R China
5.Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China
6.Lishui Hosp Tradit Chinese Med, Dept Gastroenterol, Lishui 323000, Zhejiang, Peoples R China

Wang, Guozhen,Qi, Yongshuai,Xu, Jia,et al. Neutrophil Membrane-Coated Mesoporous Silica Nanoparticles Loaded with Hydrocortisone Alleviate DSS-Induced Colitis in Mice[J]. ACS APPLIED NANO MATERIALS,2023.

Wang, Guozhen.,Qi, Yongshuai.,Xu, Jia.,Huang, Yun.,Xiong, Feng.,...&Wang, Lisheng.(2023).Neutrophil Membrane-Coated Mesoporous Silica Nanoparticles Loaded with Hydrocortisone Alleviate DSS-Induced Colitis in Mice.ACS APPLIED NANO MATERIALS.

Wang, Guozhen,et al."Neutrophil Membrane-Coated Mesoporous Silica Nanoparticles Loaded with Hydrocortisone Alleviate DSS-Induced Colitis in Mice".ACS APPLIED NANO MATERIALS (2023).