Sequential drug delivery for liver diseases

Huang, Xiaozhong1,2; Lee, Fan2; Teng, Yao1,2; Lingam, Corey Bryen4; Chen, Zijian4,5; Sun, Min1; Song, Ziwei1,2; Balachander, Gowri M.1; Leo, Hwa Liang4; Guo, Qiongyu5; Shah, Imran6; Yu, Hanry1,2,3,7,8

2019

10.1016/j.addr.2019.11.001

Advanced Drug Delivery Reviews   影响因子和分区

18728294

1872-8294

The liver performs critical physiological functions such as metabolism/detoxification and blood homeostasis/biliary excretion. A high degree of blood access means that a drug's resident time in any cell is relatively short. This short drug exposure to cells requires local sequential delivery of multiple drugs for optimal efficacy, potency, and safety. The high metabolism and excretion of drugs also impose both technical challenges and opportunities to sequential drug delivery. This review provides an overview of the sequential events in liver regeneration and the related liver diseases. Using selected examples of liver cancer, hepatitis B viral infection, fatty liver diseases, and drug-induced liver injury, we highlight efforts made for the sequential delivery of small and macromolecular drugs through different biomaterials, cells, and microdevice-based delivery platforms that allow fast delivery kinetics and rapid drug switching. As this is a nascent area of development, we extrapolate and compare the results with other sequential drug delivery studies to suggest possible application in liver diseases, wherever appropriate.
© 2019 Elsevier B.V.

Liver regeneration Drug delivery NASH Microdevice TACE Liver cancer

EI ; SCI

英语

其他

Agency for Science, Technology and Research[STAR] ; Agency for Science, Technology and Research[] ; Mechanobiology Institute, Singapore[R-714-006-008-271] ; Ministry of Health[] ; National Research Foundation Singapore[] ; [R-185-000-342-112] ; National University Health System[R-185-000-343-733] ; National Medical Research Council[R-185-000-294-511] ; Hanyang University[]

Pharmacology & Pharmacy

Pharmacology & Pharmacy

WOS:000503094100005

Elsevier B.V.

20194807758561

Blood ; Diseases ; Drug delivery ; Metabolism ; Targeted drug delivery

Biological Materials and Tissue Engineering:461.2

PHARMACOLOGY & TOXICOLOGY

EV Compendex

1.Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9-04-11, 2 Medical Drive, Singapore; 117593, Singapore
2.Institute of Bioengineering and Nanotechnology, A*STAR, The Nanos, #06-01, 31 Biopolis Way, Singapore; 138669, Singapore
3.Mechanobiology Institute, National University of Singapore, T-Lab, #05-01, 5A Engineering Drive 1, Singapore; 117411, Singapore
4.Department of Biomedical Engineering, National University of Singapore, Engineering Drive 3, Engineering Block 4, #04-08, Singapore; 117583, Singapore
5.Department of Biomedical Engineering, Southern University of Science and Technology, 1088 Xueyuan Avenue, Shenzhen; 518055, China
6.National Center for Computational Toxicology, United States Environmental Protection Agency, 4930 Old Page Rd., Durham; NC; 27703, United States
7.CAMP, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, Level 4 Enterprise Wing, Singapore; 138602, Singapore
8.Gastroenterology Department, Southern Medical University, Guangzhou; 510515, China

Huang, Xiaozhong,Lee, Fan,Teng, Yao,et al. Sequential drug delivery for liver diseases[J]. Advanced Drug Delivery Reviews,2019,149-150:72-84.

Huang, Xiaozhong.,Lee, Fan.,Teng, Yao.,Lingam, Corey Bryen.,Chen, Zijian.,...&Yu, Hanry.(2019).Sequential drug delivery for liver diseases.Advanced Drug Delivery Reviews,149-150,72-84.

Huang, Xiaozhong,et al."Sequential drug delivery for liver diseases".Advanced Drug Delivery Reviews 149-150(2019):72-84.