| 题名 | Widespread long-range cis-regulatory elements in the maize genome |
| 作者 | Ricci, William A.1; Lu, Zefu2; Ji, Lexiang3; Marand, Alexandre P.2; Ethridge, Christina L.2; Murphy, Nathalie G.2; Noshay, Jaclyn M.4; Galli, Mary5; Mejia-Guerra, Maria Katherine6; Colome-Tatche, Maria7,8; Johannes, Frank8,9; Rowley, M. Jordan10; Corces, Victor G.10; Zhai, Jixian11  ; Scanlon, Michael J.6; Buckler, Edward S.6,12,13,14; Gallavotti, Andrea5; Springer, Nathan M.4; Schmitz, Robert J.2,9 ; Zhang, Xiaoyu1
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| 通讯作者 | Schmitz, Robert J.; Zhang, Xiaoyu |
| 发表日期 | 2019-12
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| DOI | |
| 发表期刊 | |
| ISSN | 2055-026X
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| EISSN | 2055-0278
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| 卷号 | 5期号:12页码:1237-1249 |
| 摘要 | Genetic mapping studies on crops suggest that agronomic traits can be controlled by gene-distal intergenic loci. Despite the biological importance and the potential agronomic utility of these loci, they remain virtually uncharacterized in all crop species to date. Here, we provide genetic, epigenomic and functional molecular evidence to support the widespread existence of gene-distal (hereafter, distal) loci that act as long-range transcriptional cis-regulatory elements (CREs) in the maize genome. Such loci are enriched for euchromatic features that suggest their regulatory functions. Chromatin loops link together putative CREs with genes and recapitulate genetic interactions. Putative CREs also display elevated transcriptional enhancer activities, as measured by self-transcribing active regulatory region sequencing. These results provide functional support for the widespread existence of CREs that act over large genomic distances to control gene expression. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 重要成果 | ESI高被引
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| 学校署名 | 其他
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| 资助项目 | European Seventh Framework Programme[291763]
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| WOS研究方向 | Plant Sciences
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| WOS类目 | Plant Sciences
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| WOS记录号 | WOS:000501905000014
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：215
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/50732 |
| 专题 | 南方科技大学-北京大学植物与食品联合研究所 生命科学学院_生物系 |
| 作者单位 | 1.Univ Georgia, Dept Plant Biol, Athens, GA 30602 USA 2.Univ Georgia, Dept Genet, Athens, GA 30602 USA 3.Univ Georgia, Inst Bioinformat, Athens, GA 30602 USA 4.Univ Minnesota, Dept Plant & Microbial Biol, St Paul, MN 55108 USA 5.Rutgers State Univ, Waksman Inst Microbiol, Piscataway, NJ USA 6.Cornell Univ, Plant Biol Sect, Sch Integrat Plant Sci, Ithaca, NY 14853 USA 7.German Res Ctr Environm Hlth, Helmholtz Ctr Munich, Inst Computat Biol, Neuherberg, Germany 8.Tech Univ Munich, Dept Plant Sci, Freising Weihenstephan, Germany 9.Tech Univ Munich, Inst Adv Study, Garching, Germany 10.Emory Univ, Dept Biol, Atlanta, GA 30322 USA 11.Southern Univ Sci & Technol, Dept Biol, Inst Plant & Food Sci, Shenzhen, Guangdong, Peoples R China 12.Cornell Univ, Inst Genom Divers, Ithaca, NY USA 13.ARS, USDA, Robert Holley Ctr, Ithaca, NY USA 14.Cornell Univ, Dept Plant Breeding & Genet, Ithaca, NY USA |
| 推荐引用方式 GB/T 7714 |
Ricci, William A.,Lu, Zefu,Ji, Lexiang,et al. Widespread long-range cis-regulatory elements in the maize genome[J]. Nature Plants,2019,5(12):1237-1249.
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| APA |
Ricci, William A..,Lu, Zefu.,Ji, Lexiang.,Marand, Alexandre P..,Ethridge, Christina L..,...&Zhang, Xiaoyu.(2019).Widespread long-range cis-regulatory elements in the maize genome.Nature Plants,5(12),1237-1249.
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| MLA |
Ricci, William A.,et al."Widespread long-range cis-regulatory elements in the maize genome".Nature Plants 5.12(2019):1237-1249.
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| 条目包含的文件 | 条目无相关文件。 | |||||
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