Unlocking the Drug Potential of the Bryostatin Family: Recent Advances in Product Synthesis and Biomedical Applications

Wu, Rongzhen3; Chen, Hongyu4; Chang, Ninghui5; Xu, Yuzhi6; Jiao, Jiao1; Zhang, Hailong2

2019-11-19

10.1002/chem.201903128

CHEMISTRY-A EUROPEAN JOURNAL   影响因子和分区

0947-6539

1521-3765

Bryostatins are a class of naturally occurring macrocyclic lactones with a unique fast developing portfolio of clinical applications, including treatment of AIDS, Alzheimer's disease, and cancer. This comprehensive account summarizes the recent progress (2014-present) in the development of bryostatins, including their total synthesis and biomedical applications. An emphasis is placed on the discussion of bryostatin 1, the most-studied analogue to date. This review highlights the synthetic and biological challenges of bryostatins and provides an outlook on their future development.

antitumor agents bioactivity bryostatins drug discovery total synthesis

SCI ; EI

英语

第一

Nature Science Foundation of Shaanxi Province[2019JZ-01]

Chemistry

Chemistry, Multidisciplinary

WOS:000497635500001

WILEY-V C H VERLAG GMBH

20194807742019

Bioactivity ; Biotechnology ; Drug products ; Neurodegenerative diseases ; Synthesis (chemical)

Medicine and Pharmacology:461.6 ; Biotechnology:461.8 ; Chemical Reactions:802.2

CHEMISTRY

Web of Science

1.Xi An Jiao Tong Univ, Dept Chem, Sch Sci, Xian Key Lab Sustainable Energy Mat Chem, Xian 710049, Shaanxi, Peoples R China
2.Xi An Jiao Tong Univ, Sch Pharm, Xian 710061, Shaanxi, Peoples R China
3.Southern Univ Sci & Technol China, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China
4.Southern Univ Sci & Technol China, Dept Biol, Shenzhen 518055, Guangdong, Peoples R China
5.Northwestern Polytech Univ, Sch Sci, Dept Chem, Xian 710072, Shaanxi, Peoples R China
6.South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510006, Guangdong, Peoples R China

Wu, Rongzhen,Chen, Hongyu,Chang, Ninghui,et al. Unlocking the Drug Potential of the Bryostatin Family: Recent Advances in Product Synthesis and Biomedical Applications[J]. CHEMISTRY-A EUROPEAN JOURNAL,2019,26(6):1166-1195.

Wu, Rongzhen,Chen, Hongyu,Chang, Ninghui,Xu, Yuzhi,Jiao, Jiao,&Zhang, Hailong.(2019).Unlocking the Drug Potential of the Bryostatin Family: Recent Advances in Product Synthesis and Biomedical Applications.CHEMISTRY-A EUROPEAN JOURNAL,26(6),1166-1195.

Wu, Rongzhen,et al."Unlocking the Drug Potential of the Bryostatin Family: Recent Advances in Product Synthesis and Biomedical Applications".CHEMISTRY-A EUROPEAN JOURNAL 26.6(2019):1166-1195.