An IR820 Dye-Protein Complex for Second Near-Infrared Window and Photoacoustic Imaging

Du, Bulin1,2; Qu, Chunrong2; Qian, Kun2; Ren, Ying2; Li, Yesen2; Cui, Xiaohong2; He, Shuqing3,4; Wu, Yifan2; Ko, Timothy2; Liu, Ruiqi5; Li, Xuena1; Li, Yaming1; Cheng, Zhen2

2019-12-18

10.1002/adom.201901471

Advanced Optical Materials   影响因子和分区

2195-1071

Recently, much attention has been focused on the development of second near-infrared window (NIR-II, 1000-1700 nm) fluorescence imaging because of its reduced scattering, minimal absorption, and negligible autofluorescence. NIR-II bioimaging allows the visualization of deep anatomical features with an unprecedented degree of clarity. In addition to the construction of a variety of new NIR-II fluorophores, using a fluorescence tail emission greater than 1000 nm for conventional NIR-I dyes represents a promising strategy for developing an NIR-II imaging technique. Herein, the authors report tailoring a supramolecular assembly of human serum albumin (HSA) protein complexed with a sulfonated NIR-I organic dye (IR820) to produce a brilliant 21-fold increase in fluorescence for NIR-II imaging. In vivo NIR-II imaging with IR820-HSA allows noninvasive and dynamic visualization and monitoring of physiological and pathological conditions of the vascular system, lymphatic drainage system, and tumor-bearing mice, as well as image-guided tumor resection with high spatial and temporal resolution. Furthermore, photoacoustic imaging (PAI) of IR820-HSA in mouse tumor models also demonstrate good tumor accumulation. Overall, an IR820-protein complex with high biocompatibility can be easily constructed using a conventional NIR-I dye that provides a new theranostic tool with high clinical translation potential.

fluorescence imaging human serum albumin IR820 photoacoustic imaging second near-infrared window

SCI ; EI

英语

其他

Young Scholars Program of China Medical University[QGZ-2018036]

Materials Science ; Optics

Materials Science, Multidisciplinary ; Optics

WOS:000503150600001

WILEY-V C H VERLAG GMBH

20195207902587

Biocompatibility ; Cardiovascular system ; Fluorescence imaging ; Fluorophores ; Imaging techniques ; Mammals ; Photoacoustic effect ; Proteins ; Tumors ; Visualization

Biological Materials and Tissue Engineering:461.2 ; Immunology:461.9.1 ; Light/Optics:741.1 ; Imaging Techniques:746 ; Organic Compounds:804.1

Web of Science

1.China Med Univ, Hosp 1, Dept Nucl Med, Shenyang 110001, Liaoning, Peoples R China
2.Stanford Univ, Sch Med, Dept Radiol & Bio X Program, Canary Ctr Stanford Canc Early Detect,MIPS, Palo Alto, CA 94305 USA
3.Southern Univ Sci & Technol SUSTech, Acad Adv Interdisciplinary Studies, Shenzhen 518055, Guangdong, Peoples R China
4.Southern Univ Sci & Technol SUSTech, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China
5.Northeastern Univ, Coll Life & Hlth Sci, Inst Mol Med, Shenyang 110000, Liaoning, Peoples R China

Du, Bulin,Qu, Chunrong,Qian, Kun,et al. An IR820 Dye-Protein Complex for Second Near-Infrared Window and Photoacoustic Imaging[J]. Advanced Optical Materials,2019,8(4).

Du, Bulin.,Qu, Chunrong.,Qian, Kun.,Ren, Ying.,Li, Yesen.,...&Cheng, Zhen.(2019).An IR820 Dye-Protein Complex for Second Near-Infrared Window and Photoacoustic Imaging.Advanced Optical Materials,8(4).

Du, Bulin,et al."An IR820 Dye-Protein Complex for Second Near-Infrared Window and Photoacoustic Imaging".Advanced Optical Materials 8.4(2019).